Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYCR1 | P32322 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LSS | P48449 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6141789 | 0.79 | BACE1 (0.44) | TSHRKDM4EALDH1A1LMNACYP1A2 | |
| SCHEMBL18532755 | 0.77 | PYCR1 (0.67) | PYCR1TSHRKDM4ELSSALDH1A1 | |
| SCHEMBL5697695 | 0.76 | HRH3 (0.46) | — | |
| SCHEMBL6142120 | 0.74 | CRHBP (0.47) | KDM4EALDH1A1 | |
| SCHEMBL29607692 | 0.72 | ALDH1A1 (0.47) | KDM4EALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL28473856 | 0.72 | ALDH1A1 (0.47) | KDM4EALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL6141682 | 0.72 | HRH3 (0.56) | KDM4EALDH1A1PSEN1PSEN2APH1B | |
| SCHEMBL3149087 | 0.69 | PYCR1 (0.56) | PYCR1TSHRKDM4ELSSALDH1A1 | |
| SCHEMBL9513831 | 0.68 | PYCR1 (0.60) | PYCR1TSHRKDM4ELSSALDH1A1 | |
| SCHEMBL10663042 | 0.66 | PYCR1 (0.58) | PYCR1TSHRKDM4ELSSALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492785-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2005-01-05 | — | — | EP | claimed |
| WO-2003082853-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2003-10-09 | — | — | WO | claimed |
| EP-1492785-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2005-01-05 | — | — | EP | disclosed |
| WO-2003082853-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2003-10-09 | — | — | WO | disclosed |