Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 9/20 | 0.60 |
| ▸ | MMP13 | P45452 | 2/20 | 0.60 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | IGF2BP2 | Q9Y6M1 | 1/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6152695 | 0.84 | MMP12 (0.67) | MMP12MMP13ABL1HDAC6IGF2BP2 | |
| SCHEMBL6450836 | 0.83 | MMP12 (0.56) | MMP12MMP13ABL1HDAC6SCN10A | |
| SCHEMBL6141803 | 0.82 | ABL1 (0.57) | MMP12MMP13ABL1SCN10AEPHX2 | |
| SCHEMBL6468492 | 0.78 | MMP12 (0.63) | MMP12MMP13ABL1HDAC6SCN10A | |
| SCHEMBL6451590 | 0.77 | ABL1 (0.57) | MMP12MMP13ABL1SCN10A | |
| SCHEMBL6462719 | 0.76 | MMP12 (0.64) | MMP12MMP13ABL1HDAC6EPHX2 | |
| SCHEMBL6450492 | 0.76 | MMP12 (0.60) | MMP12MMP13ABL1HDAC6SCN10A | |
| SCHEMBL6142212 | 0.76 | MMP12 (0.51) | MMP12MMP13HDAC6 | |
| SCHEMBL6511171 | 0.76 | MMP12 (0.62) | MMP12MMP13ABL1HDAC6IGF2BP2 | |
| SCHEMBL6374857 | 0.75 | MMP12 (0.61) | MMP12MMP13ABL1HDAC6IGF2BP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1493739-A1 | Thiophene derivatives of aminoacids, process for the preparation thereof and compositions containing them | Warner-Lambert Company LLC (US) | 2005-01-05 | — | — | EP | claimed |
| EP-1493739-A1 | Thiophene derivatives of aminoacids, process for the preparation thereof and compositions containing them | Warner-Lambert Company LLC (US) | 2005-01-05 | — | — | EP | disclosed |