Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 10/20 | 0.56 |
| ▸ | MMP13 | P45452 | 2/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | ULK1 | O75385 | 1/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6462719 | 0.84 | MMP12 (0.64) | MMP12MMP13ABL1MAPK1ROCK2 | |
| SCHEMBL6141802 | 0.83 | MMP12 (0.60) | MMP12MMP13ABL1HDAC6SCN10A | |
| SCHEMBL6152695 | 0.78 | MMP12 (0.67) | MMP12MMP13ABL1MAPK1HDAC6 | |
| SCHEMBL6450864 | 0.78 | MMP12 (0.62) | MMP12MMP13ABL1MAPK1MMP2 | |
| SCHEMBL6456507 | 0.77 | MMP12 (0.72) | MMP12MMP13ABL1MAPK1ROCK2 | |
| SCHEMBL6663858 | 0.77 | MMP12 (0.59) | MMP12MMP13ABL1MAPK1ROCK2 | |
| SCHEMBL6456642 | 0.77 | MMP12 (0.56) | MMP12MMP13ABL1MAPK1ROCK2 | |
| SCHEMBL6458023 | 0.77 | MMP12 (0.56) | MMP12MMP13ABL1MAPK1ROCK2 | |
| SCHEMBL6450465 | 0.77 | MMP12 (0.62) | MMP12MMP13ABL1MAPK1ROCK2 | |
| SCHEMBL6141803 | 0.76 | ABL1 (0.57) | MMP12MMP13ABL1SCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534700-A1 | NOVEL THIOPHENE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | WARNER-LAMBERT COMPANY LLC (US) | 2005-06-01 | — | — | EP | claimed |
| WO-2004018448-A1 | NOVEL THIOPHENE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | WARNER-LAMBERT COMPANY LLC (US) | 2004-03-04 | — | — | WO | claimed |