SCHEMBL614218

SCHEMBL614218

CC(CCCOCC1CO1)(CCCOCC1CO1)O[SiH3]

nearest known ligand 0.57

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.57
SMN1; SMN2 Q16637 1/20 0.55
ALDH1A1 P00352 5/20 0.51
TDP1 Q9NUW8 1/20 0.51
MAPK1 P28482 1/20 0.47
TP53 P04637 2/20 0.33
MAPT P10636 2/20 0.33
HPGD P15428 2/20 0.33
MEN1 O00255 1/20 0.33
CYP1A2 P05177 1/20 0.33
KMT2A Q03164 1/20 0.33
PPARG P37231 1/20 0.33
HIF1A Q16665 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL125940 0.86 TSHR (0.57) TSHRSMN1; SMN2ALDH1A1TDP1MAPK1
SCHEMBL153464 0.83 TSHR (0.62) TSHRSMN1; SMN2ALDH1A1TDP1MAPK1
SCHEMBL614178 0.82 TSHR (0.61) TSHRSMN1; SMN2ALDH1A1TDP1MAPK1
SCHEMBL12158820 0.82 TSHR (0.65) TSHRSMN1; SMN2ALDH1A1TDP1MAPK1
SCHEMBL845307 0.81 TSHR (0.55) TSHRSMN1; SMN2ALDH1A1TDP1MAPK1
SCHEMBL16369596 0.81 TSHR (0.55) TSHRSMN1; SMN2ALDH1A1TDP1MAPK1
SCHEMBL17710340 0.81 TSHR (0.60) TSHRSMN1; SMN2ALDH1A1TDP1MAPK1
SCHEMBL613049 0.81 TSHR (0.64) TSHRSMN1; SMN2ALDH1A1TDP1MAPK1
SCHEMBL27958344 0.80 TSHR (0.69) TSHRSMN1; SMN2ALDH1A1TDP1MAPK1
SCHEMBL614617 0.80 SMN1; SMN2 (0.56) TSHRSMN1; SMN2ALDH1A1TDP1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7256238-B2 Modified block copolymer ASAHI KASEI CHEMICALS CORPORATION (JP) 2007-08-14 US claimed
EP-1199313-B1 Diene polymers and copolymers having an alkoxysilane group BRIDGESTONE CORP (JP) 2005-08-24 EP claimed
US-10072138-B2 Rubber composition for use in tire treads THE YOKOHAMA RUBBER CO., LTD (JP) 2018-09-11 US disclosed
US-20180022913-A1 Block Copolymer Composition, Molded Material, Resin Composition, and Molded Product ASAHI KASEI KABUSHIKI KAISHA (JP) 2018-01-25 US disclosed
EP-3257896-A1 BLOCK COPOLYMER COMPOSITION, MOLDING MATERIAL, RESIN COMPOSITION, AND MOLDED ARTICLE Asahi Kasei Kabushiki Kaisha (JP) 2017-12-20 EP disclosed
US-9790359-B2 Tread rubber composition and pneumatic tire SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2017-10-17 US disclosed
US-9567451-B2 Rubber composition for use in tire treads THE YOKOHAMA RUBBER CO., LTD. (JP) 2017-02-14 US disclosed
US-9493638-B2 Rubber composition for tire THE YOKOHAMA RUBBER CO., LTD. (JP) 2016-11-15 US disclosed
US-9475924-B2 Rubber composition for tire tread and pneumatic tire using the same THE YOKOHAMA RUBBER CO., LTD. (JP) 2016-10-25 US disclosed
US-9416252-B2 Rubber composition for tire tread THE YOKOHAMA RUBBER CO., LTD. (JP) 2016-08-16 US disclosed
US-9139721-B2 Rubber composition for tire treads THE YOKOHAMA RUBBER CO., LTD. (JP) 2015-09-22 US disclosed
EP-0773231-B1 Diene polymers and copolymers having an alkoxysilane group BRIDGESTONE CORP (JP) 2002-07-10 EP disclosed
EP-1199313-A2 Diene polymers and copolymers having an alkoxysilane group Bridgestone Corporation (JP) 2002-04-24 EP disclosed
EP-0767179-B1 Method for producing a rubber composition BRIDGESTONE CORP (JP) 2001-06-27 EP disclosed
US-6117927-A MODIFYING TERMINAL OF A DIENE RUBBER WITH A SILANE MODIFIER HAVING A SPECIFIC FUNCTIONALITY, BRIDGESTONE CORPORATION (JP) 2000-09-12 US disclosed
EP-0661298-B1 Diene polymers and copolymers having an alkoxysilane group BRIDGESTONE CORP (JP) 1999-03-17 EP disclosed
EP-0773231-A2 Diene polymers and copolymers having an alkoxysilane group Bridgestone Corporation (JP) 1997-05-14 EP disclosed
EP-0767179-A2 Method for producing a rubber composition Bridgestone Corporation (JP) 1997-04-09 EP disclosed
US-5508333-A NONCRACKING, WEAR RESISTANCE, HYSTERESIS-FREE; TIRES BRIDGESTONE CORPORATION (JP) 1996-04-16 US disclosed
EP-0661298-A2 Diene polymers and copolymers having an alkoxysilane group BRIDGESTONE CORPORATION (JP) 1995-07-05 EP disclosed