Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYCR1 | P32322 | 1/20 | 0.44 |
| ▸ | LSS | P48449 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18532755 | 0.76 | PYCR1 (0.67) | PYCR1LSSMEN1KMT2AKDM4E | |
| SCHEMBL6141786 | 0.74 | KDM4E (0.53) | MEN1KMT2AKDM4ETSHRALDH1A1 | |
| SCHEMBL5697692 | 0.72 | POLB (0.46) | MEN1KMT2AKDM4EALDH1A1HTT | |
| SCHEMBL6142118 | 0.71 | HSD17B3 (0.40) | MEN1KMT2A | |
| SCHEMBL6141679 | 0.68 | CHEK1 (0.49) | MEN1KMT2AKDM4ETSHRALDH1A1 | |
| SCHEMBL3149087 | 0.68 | PYCR1 (0.56) | PYCR1LSSMEN1KMT2AKDM4E | |
| SCHEMBL9513831 | 0.67 | PYCR1 (0.60) | PYCR1LSSKDM4ETSHRALDH1A1 | |
| SCHEMBL15990329 | 0.67 | PDXK (0.35) | MEN1KMT2AKDM4EALDH1A1HTT | |
| SCHEMBL8392169 | 0.66 | PYCR1 (0.55) | PYCR1LSSKDM4ETSHRALDH1A1 | |
| SCHEMBL3705816 | 0.66 | AOC3 (0.50) | MEN1KMT2AKDM4ERAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492785-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2005-01-05 | — | — | EP | claimed |
| WO-2003082853-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2003-10-09 | — | — | WO | claimed |
| EP-1492785-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2005-01-05 | — | — | EP | disclosed |
| WO-2003082853-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2003-10-09 | — | — | WO | disclosed |