Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6141771 | 0.84 | TLR7 (0.35) | POLBKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL6142118 | 0.73 | HSD17B3 (0.40) | MEN1KMT2AHDAC6 | |
| SCHEMBL15990329 | 0.72 | PDXK (0.35) | KDM4EMEN1ALDH1A1KMT2AHTT | |
| SCHEMBL6142244 | 0.72 | PYCR1 (0.44) | KDM4EMEN1ALDH1A1KMT2AHTT | |
| SCHEMBL13675363 | 0.72 | POLB (0.60) | POLBKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL6141679 | 0.70 | CHEK1 (0.49) | POLBKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL6141786 | 0.68 | KDM4E (0.53) | POLBKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL5249119 | 0.67 | AKR1B1 (0.44) | POLBKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL28972155 | 0.67 | PRKCI (0.65) | POLBKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL11266199 | 0.65 | GABRA1 (0.56) | POLBKDM4EMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667990-A2 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005027823-A2 | 3-HETEROCYCLYL-INDOLE DERIVATIVES AS INHIBITORS OF GLYCOGEN SYNTHASE KINASE-3 (GSK-3) | ASTRAZENECA AB (SE) | 2005-03-31 | — | — | WO | disclosed |