Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.52 |
| ▸ | PCNA | P12004 | 2/20 | 0.50 |
| ▸ | THRA | P10827 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGAV | P06756 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL490990 | 0.89 | ALOX5 (0.69) | ALOX5POLBTNKS2NFKB1NFKB2 | |
| SCHEMBL1270234 | 0.87 | PCNA (0.57) | PCNATHRATHRBPOLBMAPK1 | |
| SCHEMBL25363485 | 0.85 | ALOX5 (0.60) | ALOX5POLBTNKS2NFKB1NFKB2 | |
| SCHEMBL5012985 | 0.84 | THRA (0.60) | ALOX5TRPV1PCNATHRATHRB | |
| SCHEMBL14311297 | 0.81 | ALOX5 (0.56) | ALOX5TRPV1THRATHRBTNKS2 | |
| SCHEMBL17306533 | 0.80 | ALOX5 (0.55) | ALOX5TRPV1POLBTNKS2NFKB1 | |
| SCHEMBL1446398 | 0.79 | FFAR1 (0.65) | ALOX5PCNAFFAR1OR51E2GAA | |
| SCHEMBL26617184 | 0.79 | TRPV1 (0.52) | ALOX5TRPV1THRATHRBTNKS2 | |
| SCHEMBL29353616 | 0.79 | PCNA (0.50) | PCNATHRATHRBPOLBMAPK1 | |
| SCHEMBL3675317 | 0.78 | ALOX5 (0.51) | ALOX5NFKB1FFAR1OR51E2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6855822-B2 | Reacting a substituted 2-iodo-3-hydroxy benzene with a terminal alkyne in presence of a transition metal catalyst, coupling two molecule of intermediate together | VIVOQUEST, INC. (US) | 2005-02-15 | — | — | US | disclosed |
| US-20040110949-A1 | Benzo[b]furan dimers | PRESIDIO PHARMACEUTICALS, INC. | 2004-06-10 | — | — | US | disclosed |
| WO-2004000764-A2 | BENZO(b)FURAN DIMERS | VIVOQUEST, INC. (US) | 2003-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110949-A1 | Benzo[b]furan dimers | BZW2, BZW1, BPTF | ALOX5 1742/4885TRPV1 1211/4885PCNA 802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.