Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 3/20 | 0.60 |
| ▸ | THRB | P10828 | 3/20 | 0.60 |
| ▸ | PPARG | P37231 | 3/20 | 0.60 |
| ▸ | RXRA | P19793 | 2/20 | 0.60 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.60 |
| ▸ | ITGAV | P06756 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.47 |
| ▸ | CA5A | P35218 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26617184 | 0.88 | TRPV1 (0.52) | THRATHRBPPARGRXRAITGB3 | |
| SCHEMBL1278855 | 0.88 | GAA (0.66) | THRATHRBPPARGRXRAITGB3 | |
| SCHEMBL8773706 | 0.86 | THRB (0.71) | THRATHRBPPARGRXRAITGB3 | |
| SCHEMBL8072165 | 0.84 | GAA (0.67) | THRATHRBPPARGRXRAITGB3 | |
| SCHEMBL31103566 | 0.84 | GAA (0.67) | THRATHRBPPARGRXRAITGB3 | |
| SCHEMBL6143465 | 0.84 | ALOX5 (0.56) | THRATHRBPPARGRXRAITGB3 | |
| SCHEMBL5490546 | 0.83 | GAA (0.60) | THRATHRBPPARGRXRAITGB3 | |
| SCHEMBL13586551 | 0.81 | GAA (0.58) | THRATHRBPPARGRXRAITGB3 | |
| SCHEMBL1525495 | 0.80 | GAA (0.57) | THRATHRBPPARGGAAALDH1A1 | |
| SCHEMBL11156508 | 0.80 | GAA (0.57) | THRATHRBPPARGRXRAITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150104439-A1 | PHARMACEUTICAL REMOVAL OF NEURONAL EXTENSIONS FROM A DEGENERATING DISC | WARSAW ORTHOPEDIC INC (US) | 2015-04-16 | — | — | US | claimed |
| US-20070298407-A1 | Diagnostic kits and methods for diagnosis of axial pain with or without radiculopathy | MEDTRONIC, INC. | 2007-12-27 | — | — | US | claimed |
| US-20070287991-A1 | Devices and methods for detection of markers of axial pain with or without radiculopathy | MEDTRONIC, INC. | 2007-12-13 | — | — | US | claimed |
| US-9730986-B2 | Pharmaceutical removal of neuronal extensions from a degenerating disc | WARSAW ORTHOPEDIC, INC. (US) | 2017-08-15 | — | — | US | disclosed |
| US-9597352-B2 | Compositions and methods for treating pain | WARSAW ORTHOPEDIC, INC. (US) | 2017-03-21 | — | — | US | disclosed |
| US-20150104439-A1 | PHARMACEUTICAL REMOVAL OF NEURONAL EXTENSIONS FROM A DEGENERATING DISC | WARSAW ORTHOPEDIC INC (US) | 2015-04-16 | — | — | US | disclosed |
| US-8916611-B2 | Pharmaceutical removal of neuronal extensions from a degenerating disc | WARSAW ORTHOPEDIC, INC. (US) | 2014-12-23 | — | — | US | disclosed |
| US-8545831-B2 | Compositions and methods for treating a damaged cardiovascular element | WARSAW ORTHOPEDIC, INC. (US) | 2013-10-01 | — | — | US | disclosed |
| US-8333697-B2 | Diagnostic kits and methods for diagnosis of axial pain with or without radiculopathy | WARSAW ORTHOPEDIC, INC. (US) | 2012-12-18 | — | — | US | disclosed |
| EP-1890712-A1 | COMPOSITIONS AND METHODS FOR TREATING PAIN | Warsaw Orthopedic, Inc. (US) | 2008-02-27 | — | — | EP | disclosed |
| US-20070298407-A1 | Diagnostic kits and methods for diagnosis of axial pain with or without radiculopathy | MEDTRONIC, INC. | 2007-12-27 | — | — | US | disclosed |
| US-20070293428-A1 | Methods of treating joint pain in a subject by using an anti-angiogenic agent | ZANELLA JOHN M | 2007-12-20 | — | — | US | disclosed |
| US-20070287991-A1 | Devices and methods for detection of markers of axial pain with or without radiculopathy | MEDTRONIC, INC. | 2007-12-13 | — | — | US | disclosed |
| US-20070012323-A1 | Compositions and methods for treating a damaged cardiovascular element | WARSAW ORTHOPEDIC, INC. | 2007-01-18 | — | — | US | disclosed |
| US-20060280718-A1 | Compositions and methods for treating pain | WARSAW ORTHOPEDIC, INC. | 2006-12-14 | — | — | US | disclosed |
| WO-2006130600-A1 | COMPOSITIONS AND METHODS FOR TREATING PAIN | WARSAW ORTHOPEDIC, INC. (US) | 2006-12-07 | — | — | WO | disclosed |
| WO-2006130599-A2 | COMPOSITIONS AND METHODS FOR TREATING A DAMAGED CARDIOVASCULAR ELEMENT | WARSAW ORTHOPEDIC, INC. (US) | 2006-12-07 | — | — | WO | disclosed |