Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 12/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | CDH1 | P12830 | 1/20 | 0.41 |
| ▸ | APC | P25054 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12691935 | 0.87 | KDR (0.49) | DHODHRAB9ASMN1; SMN2KDM4EPOLB | |
| SCHEMBL3294243 | 0.85 | DHODH (0.43) | DHODHFFAR4GRM1BACE1MEN1 | |
| SCHEMBL11789345 | 0.85 | PDE10A (0.49) | DHODHCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL2339243 | 0.82 | KDM4E (0.45) | DHODHCYP1A2CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL899644 | 0.81 | BACE1 (0.52) | SMN1; SMN2KDM4EPOLBGRM5GRM1 | |
| SCHEMBL3400194 | 0.81 | PRKCZ (0.52) | DHODHNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL14710197 | 0.79 | DGAT1 (0.51) | PTGDR2POLBBACE1LMNA | |
| SCHEMBL2346052 | 0.78 | DHODH (0.46) | DHODHCYP1A2CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL19643463 | 0.77 | FFAR4 (0.49) | DHODHCYP1A2CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL11790564 | 0.76 | ALDH1A1 (0.47) | DHODHKDM4EPOLBLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194414-B1 | PROCESS FOR PREPARING 2-AMINO-4-(4-FLUORPHENYL)-6-ALKYLPYRIMIDINE-5-CARBOXYLATE | LONZA AG (CH) | 2005-10-19 | — | — | EP | disclosed |