Sugi Predict

Sugi Predict / Compounds / SCHEMBL6143620

SCHEMBL6143620

SCHEMBL6143620

COc1ccc(C2COc3cc(OC(=O)C(C)(C)C)ccc3C2(O)Cc2ccc(O)cc2)cc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALOX15 P16050 3/20 0.37
▸ ALOX12 P18054 3/20 0.37
▸ GRIN2B Q13224 1/20 0.36
▸ MEN1 O00255 2/20 0.36
▸ KMT2A Q03164 2/20 0.36
▸ ELANE P08246 3/20 0.36
▸ KCNH2 Q12809 1/20 0.35
▸ TRPV1 Q8NER1 1/20 0.35
▸ ALDH1A1 P00352 2/20 0.34
▸ CYP19A1 P11511 1/20 0.34
▸ GAA P10253 1/20 0.34
▸ ESR1 P03372 2/20 0.34
▸ ESR2 Q92731 2/20 0.34
▸ CYP3A4 P08684 3/20 0.33
▸ MAPT P10636 2/20 0.33
▸ HPGD P15428 2/20 0.33
▸ USP2 O75604 1/20 0.33
▸ TP53 P04637 1/20 0.33
▸ ADRA2A P08913 1/20 0.33
▸ ADRA2C P18825 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6142878 0.92 ADRA2A (0.38) MEN1KMT2AELANECYP19A1GAA
SCHEMBL6142880 0.92 ADRA2A (0.38) MEN1KMT2AELANECYP19A1GAA
SCHEMBL6142881 0.92 ADRA2A (0.38) MEN1KMT2AELANECYP19A1GAA
SCHEMBL6143520 0.91 HIF1A (0.40) CYP19A1
SCHEMBL6143036 0.86 ESR1 (0.53) KCNH2ESR1ESR2ADRA2ASLC6A4
SCHEMBL6144599 0.85 HIF1A (0.42) ADRA2AADRA2CSLC6A4
SCHEMBL6144595 0.85 HIF1A (0.42) ADRA2AADRA2CSLC6A4
SCHEMBL6142890 0.78 ESR1 (0.52) KCNH2ESR1ESR2ADRA2ASLC6A4
SCHEMBL6142894 0.78 ESR1 (0.52) KCNH2ESR1ESR2ADRA2ASLC6A4
SCHEMBL6142892 0.78 ESR1 (0.52) KCNH2ESR1ESR2ADRA2ASLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6951883-B2 2H-1-benzopyran derivatives processes for their preparation and pharmaceutical compositions thereof CHIESI FARMACEUTICI S.P.A. (IT) 2005-10-04 — — US disclosed
EP-1355906-B1 2H-1-BENZOPYRAN DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF CHIESI FARMA SPA (IT) 2005-01-12 — — EP disclosed
US-20040106595-A1 2H-1-benzopyran derivatives processes for their preparation and pharmaceutical compositions thereof CHIESI FARMACEUTICI S.P.A. (IT) 2004-06-03 — — US disclosed
EP-1355906-A1 2H-1-BENZOPYRAN DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF CHIESI FARMACEUTICI S.p.A. (IT) 2003-10-29 — — EP disclosed
EP-1281710-A1 2H-1-benzopyran derivatives, processes for their preparation and pharmaceutical compositions thereof CHIESI FARMACEUTICI S.p.A. (IT) 2003-02-05 — — EP disclosed
WO-2002059113-A1 2H-1-BENZOPYRAN DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF CHIESI FARMACEUTICI S.P.A. (IT) 2002-08-01 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040106595-A1 2H-1-benzopyran derivatives processes for their preparation and pharmaceutical compositions thereof CYP19A1, BRCA1, HPD ALOX15 420/4885ALOX12 443/4885GRIN2B 4387/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.