Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 14/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 12/20 | 0.53 |
| ▸ | MMP1 | P03956 | 3/20 | 0.43 |
| ▸ | MMP9 | P14780 | 3/20 | 0.43 |
| ▸ | MMP13 | P45452 | 3/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6142892 | 0.93 | ESR1 (0.52) | ESR1ESR2LTA4HPGRCHRM2 | |
| SCHEMBL6142894 | 0.93 | ESR1 (0.52) | ESR1ESR2LTA4HPGRCHRM2 | |
| SCHEMBL6142890 | 0.93 | ESR1 (0.52) | ESR1ESR2LTA4HPGRCHRM2 | |
| SCHEMBL6143620 | 0.86 | ALOX15 (0.37) | ESR1ESR2ADRA2ASLC6A4KCNH2 | |
| SCHEMBL6143520 | 0.84 | HIF1A (0.40) | MAOB | |
| Hydrochloric Acid SCHEMBL6490786 | 0.80 | ESR1 (0.52) | ESR1ESR2PGRCHRM2HTR1A | |
| SCHEMBL6143511 | 0.80 | ESR1 (0.59) | ESR1ESR2 | |
| SCHEMBL6143512 | 0.80 | ESR1 (0.59) | ESR1ESR2 | |
| SCHEMBL6143513 | 0.80 | ESR1 (0.59) | ESR1ESR2 | |
| SCHEMBL6142703 | 0.80 | ESR1 (0.51) | ESR1ESR2PGRCHRM2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6951883-B2 | 2H-1-benzopyran derivatives processes for their preparation and pharmaceutical compositions thereof | CHIESI FARMACEUTICI S.P.A. (IT) | 2005-10-04 | — | — | US | disclosed |
| EP-1355906-B1 | 2H-1-BENZOPYRAN DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | CHIESI FARMA SPA (IT) | 2005-01-12 | — | — | EP | disclosed |
| US-20040106595-A1 | 2H-1-benzopyran derivatives processes for their preparation and pharmaceutical compositions thereof | CHIESI FARMACEUTICI S.P.A. (IT) | 2004-06-03 | — | — | US | disclosed |
| EP-1355906-A1 | 2H-1-BENZOPYRAN DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | CHIESI FARMACEUTICI S.p.A. (IT) | 2003-10-29 | — | — | EP | disclosed |
| EP-1281710-A1 | 2H-1-benzopyran derivatives, processes for their preparation and pharmaceutical compositions thereof | CHIESI FARMACEUTICI S.p.A. (IT) | 2003-02-05 | — | — | EP | disclosed |
| WO-2002059113-A1 | 2H-1-BENZOPYRAN DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2002-08-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106595-A1 | 2H-1-benzopyran derivatives processes for their preparation and pharmaceutical compositions thereof | CYP19A1, BRCA1, HPD | ESR1 16/4885ESR2 53/4885MMP1 3375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.