Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6154648 | 0.86 | CYP4F2 (0.42) | KMT2ACYP4F2CYP4A11MAP2K1ITGB3 | |
| SCHEMBL6143844 | 0.84 | HRH2 (0.44) | GPR119 | |
| SCHEMBL6153832 | 0.84 | HRH2 (0.44) | GPR119 | |
| SCHEMBL6142857 | 0.84 | CYP4F2 (0.40) | KMT2ACYP4F2CYP4A11MAP2K1ITGB3 | |
| SCHEMBL6143554 | 0.83 | CA12 (0.38) | GPR119HRH4 | |
| SCHEMBL6143437 | 0.82 | ACP1 (0.40) | KMT2AHRH4 | |
| SCHEMBL6143003 | 0.81 | ACP1 (0.39) | KMT2ACYP4F2CYP4A11MAP2K1HPGD | |
| SCHEMBL6143541 | 0.80 | P2RY12 (0.36) | GPR119KMT2ACYP4F2CYP4A11ITGB3 | |
| SCHEMBL6143001 | 0.80 | CHEK2 (0.40) | — | |
| SCHEMBL6991041 | 0.80 | GPR119 (0.34) | GPR119CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585731-A2 | HISTAMINE H3 RECEPTOR ANTAGONISTS, PREPARATON AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004026837-A2 | HISTAMINE H3 RECEPTOR ANTAGONISTS, PREPARATON AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2004-04-01 | — | — | WO | disclosed |