Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 2/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPY1R | P25929 | 5/20 | 0.35 |
| ▸ | ACP1 | P24666 | 3/20 | 0.35 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6142857 | 0.89 | CYP4F2 (0.40) | CYP4F2CYP4A11KMT2AMAP2K1ITGB3 | |
| SCHEMBL6142980 | 0.87 | F10 (0.43) | KMT2ACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL6143785 | 0.86 | GPR119 (0.39) | CYP4F2CYP4A11KMT2AMAP2K1ITGB3 | |
| SCHEMBL6143003 | 0.86 | ACP1 (0.39) | CYP4F2CYP4A11KMT2AMAP2K1HPGD | |
| SCHEMBL6143437 | 0.85 | ACP1 (0.40) | KMT2AACP1P2RY12 | |
| SCHEMBL6143729 | 0.85 | KMT2A (0.36) | CYP4F2CYP4A11KMT2AMAP2K1ITGB3 | |
| SCHEMBL6143541 | 0.83 | P2RY12 (0.36) | CYP4F2CYP4A11KMT2AITGB3ITGA2B | |
| SCHEMBL6143502 | 0.81 | MAP2K1 (0.38) | KMT2AMAP2K1HPGDNPY1RACP1 | |
| SCHEMBL6143453 | 0.81 | NPY1R (0.38) | MAP2K1NPY1RACP1 | |
| SCHEMBL6153832 | 0.79 | HRH2 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585731-A2 | HISTAMINE H3 RECEPTOR ANTAGONISTS, PREPARATON AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004026837-A2 | HISTAMINE H3 RECEPTOR ANTAGONISTS, PREPARATON AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2004-04-01 | — | — | WO | disclosed |