Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2A | Q9UQM7 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 2/20 | 0.37 |
| ▸ | MMP9 | P14780 | 2/20 | 0.37 |
| ▸ | MMP13 | P45452 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5371501 | 0.76 | TSHR (0.63) | CAMK2ATSHRCAMK2GMAPK1KCNA5 | |
| SCHEMBL5363537 | 0.75 | TSHR (0.51) | CAMK2ATSHRCAMK2GMAPK1KCNA5 | |
| SCHEMBL5363541 | 0.75 | TSHR (0.51) | CAMK2ATSHRCAMK2GMAPK1KCNA5 | |
| SCHEMBL6151070 | 0.66 | HTR2A (0.43) | CAMK2ATSHRCAMK2GMAPK1ESR1 | |
| SCHEMBL10675547 | 0.66 | REN (0.51) | ALDH1A1HTR2CMAPT | |
| SCHEMBL10676698 | 0.66 | REN (0.51) | ALDH1A1HTR2CMAPT | |
| SCHEMBL10675553 | 0.66 | REN (0.51) | ALDH1A1HTR2CMAPT | |
| SCHEMBL10675560 | 0.66 | REN (0.51) | ALDH1A1HTR2CMAPT | |
| SCHEMBL10676707 | 0.66 | REN (0.51) | ALDH1A1HTR2CMAPT | |
| SCHEMBL5379409 | 0.65 | TSHR (0.54) | TSHRMAPK1ALDH1A1PGRCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1594840-A1 | PIPERIDINE-BENZENESULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-11-16 | — | — | EP | disclosed |
| WO-2004072034-A1 | PIPERIDINE-BENZENESULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-08-26 | — | — | WO | disclosed |