Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.43 |
| ▸ | SLC6A5 | Q9Y345 | 3/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.40 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.39 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.39 |
| ▸ | MCOLN1 | Q9GZU1 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5363541 | 0.89 | TSHR (0.51) | HTR2AHTR2CHTR7SLC6A9SLC6A5 | |
| SCHEMBL5363537 | 0.89 | TSHR (0.51) | HTR2AHTR2CHTR7SLC6A9SLC6A5 | |
| SCHEMBL6156542 | 0.79 | ESR1 (0.53) | SLC6A9SLC6A5NR1H3ESR1MCOLN2 | |
| SCHEMBL5741677 | 0.76 | SLC6A9 (0.43) | HTR2AHTR2CHTR7SLC6A9SLC6A5 | |
| SCHEMBL5741682 | 0.76 | SLC6A9 (0.43) | HTR2AHTR2CHTR7SLC6A9SLC6A5 | |
| SCHEMBL1631700 | 0.71 | HTT (0.55) | HCRTR1HCRTR2MAPK1UTS2RHPGD | |
| SCHEMBL7139282 | 0.71 | ACHE (0.49) | HTR2AKDM4EALDH1A1 | |
| SCHEMBL6150897 | 0.70 | MEN1 (0.44) | SLC6A9SLC6A5UTS2RALDH1A1 | |
| SCHEMBL6151344 | 0.70 | MEN1 (0.44) | SLC6A9SLC6A5UTS2RALDH1A1 | |
| SCHEMBL7164480 | 0.70 | ACHE (0.55) | HTR2AHTR2CTSHRMAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1594840-A1 | PIPERIDINE-BENZENESULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-11-16 | — | — | EP | disclosed |
| WO-2004072034-A1 | PIPERIDINE-BENZENESULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-08-26 | — | — | WO | disclosed |