Diphenylmethane

Diphenylmethane

SCHEMBL6151324

COc1ccccc1C(C)c1ccccc1.c1ccc(Cc2ccccc2)cc1

nearest known ligand 0.51

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.51
TDO2 P48775 1/20 0.51
LTA4H P09960 1/20 0.47
CYP2D6 P10635 2/20 0.46
CYP2C19 P33261 2/20 0.46
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
SLC6A2 P23975 2/20 0.42
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
TSHR P16473 1/20 0.42
SLC6A4 P31645 1/20 0.42
SLC6A3 Q01959 1/20 0.42
L3MBTL1 Q9Y468 2/20 0.41
ATM Q13315 1/20 0.41
CALM1 P0DP23 1/20 0.41
PMP22 Q01453 1/20 0.41
POLB P06746 1/20 0.41
HTT P42858 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5941442 0.89 IDO1 (0.56) IDO1TDO2MEN1KMT2ATSHR
SCHEMBL28670888 0.89 IDO1 (0.56) IDO1TDO2MEN1KMT2ATSHR
Biphenyl SCHEMBL6151323 0.82 IDO1 (0.50) IDO1TDO2CYP2D6CYP2C19MEN1
SCHEMBL19172035 0.77 TYR (0.44) IDO1TDO2MEN1KMT2ASLC6A2
SCHEMBL9303081 0.77 CA1 (0.60) IDO1TDO2MEN1KMT2ATSHR
SCHEMBL4657385 0.77 L3MBTL1 (0.44) SLC6A4L3MBTL1CALM1
SCHEMBL8767137 0.75 CALM1 (0.55) LTA4HSLC6A2SLC6A4SLC6A3CALM1
SCHEMBL27993537 0.75 CYP2D6 (0.51) IDO1TDO2CYP2D6CYP2C19MEN1
SCHEMBL27286649 0.74 NPC1 (0.47) IDO1TDO2MEN1KMT2ACYP1A2
SCHEMBL10541465 0.74 TYR (0.46) IDO1TDO2CYP2D6CYP2C19MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050157999-A1 Graded index polymer optical fiber and a method of making the same GENERAL COMPONENTS, INC. 2005-07-21 US claimed
US-20030132536-A1 Method of making a graded index polymer optical fiber GENERAL COMPONENTS, INC. 2003-07-17 US claimed
US-20030134119-A1 Graded index polymer optical fiber and a method of making the same GENERAL COMPONENTS, INC. 2003-07-17 US claimed
EP-1472080-A4 GRADED INDEX POLYMER OPTICAL FIBER AND A METHOD OF MAKING THE SAME GEN COMPONENTS INC (US) 2005-10-12 EP disclosed
US-20050157999-A1 Graded index polymer optical fiber and a method of making the same GENERAL COMPONENTS, INC. 2005-07-21 US disclosed
EP-0956025-B1 METHOD FOR IMMUNOSUPPRESSING IMMUNE MODULATION INC (US) 2005-01-05 EP disclosed
EP-1472080-A1 GRADED INDEX POLYMER OPTICAL FIBER AND A METHOD OF MAKING THE SAME General Components Inc. (US) 2004-11-03 EP disclosed
US-20030132536-A1 Method of making a graded index polymer optical fiber GENERAL COMPONENTS, INC. 2003-07-17 US disclosed
WO-2003057473-A1 GRADED INDEX POLYMER OPTICAL FIBER AND A METHOD OF MAKING THE SAME GENERAL COMPONENTS INC. (US) 2003-07-17 WO disclosed
US-20030134119-A1 Graded index polymer optical fiber and a method of making the same GENERAL COMPONENTS, INC. 2003-07-17 US disclosed