SCHEMBL6151877

SCHEMBL6151877

Cc1ccc2c(c1)-c1[nH]c3ccccc3c1C2C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 2/20 0.47
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
POLB P06746 2/20 0.43
NPC1 O15118 1/20 0.43
MAPT P10636 3/20 0.42
KDM4E B2RXH2 2/20 0.42
GAA P10253 4/20 0.40
MGAM O43451 2/20 0.40
SI P14410 2/20 0.40
MGAM2 Q2M2H8 2/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
HPGD P15428 2/20 0.37
GSK3B P49841 2/20 0.37
CDK5 Q00535 2/20 0.37
CDK5R1 Q15078 2/20 0.37
PARP14 Q460N5 1/20 0.37
GSK3A P49840 1/20 0.37
CTSV O60911 1/20 0.37
CTSL P07711 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7733259 0.82 MEN1 (0.44) MEN1KMT2AMAPTKDM4EALDH1A1
SCHEMBL6152024 0.72 KMT2A (0.40) KIF11MEN1KMT2APOLBNPC1
SCHEMBL23272971 0.68 ACHE (0.41) CYP1A2ALDH1A1ALOX15TDP1
SCHEMBL2595994 0.68 KIF11 (0.57) KIF11MEN1KMT2APOLBNPC1
SCHEMBL24633215 0.68 ELANE (0.45) MEN1KMT2APOLBMAPTHPGD
SCHEMBL2787277 0.67 KIF11 (0.41) KIF11MEN1KMT2APOLBNPC1
SCHEMBL27951196 0.66 PARP14 (0.60) KIF11MEN1KMT2APOLBNPC1
SCHEMBL14028585 0.66 SERPINE1 (0.40) MEN1KMT2AKDM4EGAACYP1A2
SCHEMBL29563317 0.65 KIF11 (0.77) KIF11MEN1KMT2APOLBNPC1
SCHEMBL607346 0.65 KIF11 (1.00) KIF11MEN1KMT2APOLBNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1543045-A1 OLEFIN POLYMERIZATION PROCESS Equistar Chemicals, LP (US) 2005-06-22 EP disclosed
US-6765074-B2 SUPPORTED INDENOINDOLYL CATALYST SYSTEM AND AN ORGANOBORON OR ORGANOALUMINUM-TREATED SOLID EQUISTAR CHEMICALS, LP 2004-07-20 US disclosed
EP-1412399-A1 SUPPORTED OLEFIN POLYMERIZATION CATALYSTS Equistar Chemicals, LP (US) 2004-04-28 EP disclosed
WO-2004029102-A1 OLEFIN POLYMERIZATION PROCESS EQUISTAR CHEMICALS, LP (US) 2004-04-08 WO disclosed
US-20040063876-A1 Olefin polymerization process EQUISTAR CHEMICALS, LP 2004-04-01 US disclosed
US-6583242-B2 Alumoxane, organometallic complex containing an indenoindolyl ligand, an activator; copolymerizing ethylene with a C3-C10 alpha-olefin EQUISTAR CHEMICALS, LP 2003-06-24 US disclosed
US-20030050413-A1 Supported olefin polymerization catalysts EQUISTAR CHEMICALS, LP 2003-03-13 US disclosed
WO-2003011921-A1 SUPPORTED OLEFIN POLYMERIZATION CATALYSTS EQUISTAR CHEMICALS, LP (US) 2003-02-13 WO disclosed
US-6376629-B2 ORGANOMETALLIC COMPOUND EQUISTAR CHEMICALS, LP 2002-04-23 US disclosed
US-20010007848-A1 Single-site catalysts for olefin polymerization EQUISTAR CHEMICALS, L.P. 2001-07-12 US disclosed
US-6232260-B1 ORGANOMETALLIC COMPLEX COMPRISES A GROUP 3 TO 10 TRANSITION OR LANTHANIDE METAL, M, AND AT LEAST ONE INDENOINDOLYL LIGAND THAT IS .PI.-BONDED TO M. EQUISTAR CHEMICALS, L.P. 2001-05-15 US disclosed
WO-2001027125-A1 SINGLE-SITE CATALYSTS FOR OLEFIN POLYMERIZATION EQUISTAR CHEMICALS, L.P. (US) 2001-04-19 WO disclosed