SCHEMBL6152001

SCHEMBL6152001

Nc1cc(Cl)c(O)c(Cl)c1.Nc1ccc(O)c(Cl)c1

nearest known ligand 0.83

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.83
CA2 P00918 1/20 0.83
THRB P10828 3/20 0.70
CYP3A4 P08684 7/20 0.50
TSHR P16473 5/20 0.50
HSD17B10 Q99714 7/20 0.48
PDE10A Q9Y233 1/20 0.45
ALDH1A1 P00352 5/20 0.44
ALOX15 P16050 4/20 0.44
RECQL P46063 3/20 0.44
HPGD P15428 3/20 0.44
CASP1 P29466 3/20 0.44
LCK P06239 1/20 0.42
SRC P12931 1/20 0.42
PRKACA P17612 1/20 0.42
PRKACG P22612 1/20 0.42
PRKACB P22694 1/20 0.42
TTR P02766 1/20 0.42
CYP2C9 P11712 2/20 0.41
CYP2C19 P33261 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL94042 0.91
Ammonia Solution, Strong SCHEMBL5009699 0.89 CA2 (0.95) CA1CA2THRBCYP3A4TSHR
Hydrochloric Acid SCHEMBL6653408 0.89 CA1 (0.95) CA1CA2THRBCYP3A4TSHR
Hydrochloric Acid SCHEMBL5422224 0.89 CA1 (0.95) CA1CA2THRBCYP3A4TSHR
SCHEMBL27271816 0.89 CA2 (0.95) CA1CA2THRBCYP3A4TSHR
SCHEMBL93999 0.83 THRB (1.00) CA1CA2THRBCYP3A4TSHR
4-Aminophenol SCHEMBL11828251 0.83 CA1 (0.83) CA1CA2THRBCYP3A4TSHR
SCHEMBL5271617 0.81 THRB (0.94) CA1CA2THRBCYP3A4TSHR
SCHEMBL9453347 0.81 THRB (0.94) CA1CA2THRBCYP3A4TSHR
Hydrochloric Acid SCHEMBL7755405 0.81 THRB (0.94) CA1CA2THRBCYP3A4TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1309540-B1 OXIDIZING COLORANT HENKEL KGAA (DE) 2005-11-02 EP claimed