Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 3/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.44 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Robenacoxib SCHEMBL31121793 | 0.87 | PTGS2 (0.50) | CXCL8PTGS2ABCB11PTGS1PPARG | |
| Robenacoxib SCHEMBL6036596 | 0.87 | PTGS2 (0.50) | CXCL8PTGS2ABCB11PTGS1PPARG | |
| SCHEMBL7213102 | 0.85 | PTGS2 (0.60) | CXCL8PTGS2ABCB11PTGS1PPARG | |
| SCHEMBL1034053 | 0.83 | PTGS2 (0.52) | CXCL8PTGS2ABCB11PTGS1PPARG | |
| SCHEMBL21650216 | 0.83 | PTGS2 (0.49) | CXCL8PTGS2ABCB11PTGS1PPARG | |
| SCHEMBL3873443 | 0.81 | PTGS2 (0.49) | CXCL8PTGS2ABCB11PTGS1PPARG | |
| SCHEMBL3869439 | 0.80 | PTGS2 (0.46) | CXCL8PTGS2ABCB11PTGS1PPARG | |
| SCHEMBL3871405 | 0.80 | CXCL8 (0.39) | CXCL8PTGS2ABCB11PTGS1PPARG | |
| SCHEMBL3870953 | 0.78 | PTGS2 (0.40) | CXCL8PTGS2ABCB11PTGS1PPARG | |
| SCHEMBL3872484 | 0.78 | PTGS2 (0.44) | CXCL8PTGS2ABCB11PTGS1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575581-A1 | COMBINATIONS OF VALSARTAN WITH COX-2 INHIBITORS | Novartis AG (CH) | 2005-09-21 | — | — | EP | claimed |
| WO-2004054575-A1 | COMBINATIONS OF VALSARTAN WITH COX-2 INHIBITORS | NOVARTIS AG (CH) | 2004-07-01 | — | — | WO | claimed |