Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | DRD1 | P21728 | 2/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6152882 | 0.93 | POLB (0.39) | PTAFRADRA2AADRA1AADRA2CADRA1D | |
| SCHEMBL6153062 | 0.89 | HPGD (0.34) | HPGDMEN1GAAKMT2AHTR4 | |
| SCHEMBL6153190 | 0.87 | SMN1; SMN2 (0.37) | PTAFRADRA2AADRA1AADRA2CADRA1D | |
| SCHEMBL6155788 | 0.84 | PTAFR (0.33) | PTAFRADRA2AADRA1AADRA2CADRA1D | |
| SCHEMBL7245208 | 0.82 | POLB (0.39) | MEN1KMT2AL3MBTL1KDM4EHRH3 | |
| SCHEMBL6152944 | 0.82 | ADRA1A (0.36) | ADRA2AADRA1AADRA2CADRA1DADRA1B | |
| SCHEMBL7245220 | 0.81 | TBXA2R (0.47) | PTAFRADRA2AADRA1AADRA2CADRA1D | |
| SCHEMBL6154503 | 0.79 | TBXA2R (0.36) | PTAFRADRA2AADRA1AADRA2CADRA1D | |
| SCHEMBL6152973 | 0.79 | PTAFR (0.32) | PTAFRADRA2AADRA1AADRA2CADRA1D | |
| SCHEMBL6153142 | 0.79 | CYP2C9 (0.37) | ADRA2AADRA1AADRA2CADRA1DADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307449-B1 | 1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMA (JP) | 2005-12-07 | — | — | EP | disclosed |
| EP-1307449-A1 | 1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002012235-A1 | 1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 2002-02-14 | — | — | WO | disclosed |