Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 4/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6154618 | 0.92 | KDM4E (0.36) | ADRA1ACYP2C9KDM4EHSD17B10MEN1 | |
| SCHEMBL6153142 | 0.88 | CYP2C9 (0.37) | ADRA1ACYP2C9KDM4EHSD17B10MEN1 | |
| SCHEMBL6152968 | 0.88 | SLC6A4 (0.35) | ADRA1ACYP2C9KDM4EHSD17B10MEN1 | |
| SCHEMBL6153461 | 0.86 | CYP4F2 (0.34) | ADRA1ACYP2C9KDM4EHSD17B10MEN1 | |
| SCHEMBL7241116 | 0.85 | KDM4E (0.41) | ADRA1AKDM4EHSD17B10ABCB11TBXA2R | |
| SCHEMBL6940628 | 0.84 | CYP2C9 (0.36) | ADRA1ACYP2C9KDM4EHSD17B10MEN1 | |
| SCHEMBL6946460 | 0.83 | PTGS2 (0.39) | ADRA1ACYP2C9KDM4EHSD17B10MEN1 | |
| SCHEMBL7132448 | 0.82 | CXCL8 (0.34) | ADRA1ACYP2C9KDM4EHSD17B10MEN1 | |
| SCHEMBL6938668 | 0.82 | PTGS2 (0.38) | ADRA1ACYP2C9KDM4EHSD17B10MEN1 | |
| SCHEMBL6154669 | 0.82 | MEN1 (0.36) | ADRA1ACYP2C9KDM4EHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307449-B1 | 1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMA (JP) | 2005-12-07 | — | — | EP | disclosed |
| EP-1307449-A1 | 1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002012235-A1 | 1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 2002-02-14 | — | — | WO | disclosed |