Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 4/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.40 |
| ▸ | HTR3B | O95264 | 2/20 | 0.40 |
| ▸ | HTR3A | P46098 | 2/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6153125 | 1.00 | CHRNA7 (0.41) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL5986813 | 1.00 | CHRNA7 (0.41) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL5986807 | 1.00 | CHRNA7 (0.41) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL6152530 | 0.87 | HTR3A (0.41) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL6152533 | 0.87 | HTR3A (0.41) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL5988093 | 0.87 | HTR3A (0.41) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL5988097 | 0.87 | HTR3A (0.41) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL9412007 | 0.82 | MMP1 (0.49) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL5988419 | 0.81 | CHRNA7 (0.52) | CHRNA7HTR3ACHRM2CHRM1CHRM3 | |
| SCHEMBL6152578 | 0.81 | CHRNA7 (0.52) | CHRNA7HTR3ACHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1233964-B1 | NEW USE AND NOVEL N-AZABICYCLO-AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-06-22 | — | — | EP | claimed |
| US-6683090-B1 | N-(1-AZABICYCLO(2.2.2)OCT-3-YL)PROPENAMIDE DERIVATIVES; PSYCHOTIC AND INTELLECTUAL IMPAIRMENT DISORDERS | ASTRAZENECA AB (SE) | 2004-01-27 | — | — | US | claimed |
| EP-1233964-B1 | NEW USE AND NOVEL N-AZABICYCLO-AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-06-22 | — | — | EP | disclosed |
| US-6683090-B1 | N-(1-AZABICYCLO(2.2.2)OCT-3-YL)PROPENAMIDE DERIVATIVES; PSYCHOTIC AND INTELLECTUAL IMPAIRMENT DISORDERS | ASTRAZENECA AB (SE) | 2004-01-27 | — | — | US | disclosed |