Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.47 |
| ▸ | HTR3B | O95264 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.47 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7258870 | 0.82 | LMNA (0.64) | LMNACHRNA7MAPTSIGMAR1HTR3E | |
| SCHEMBL19615164 | 0.79 | LMNA (0.52) | LMNAMAPTALOX15ALDH1A1PKM | |
| SCHEMBL6153220 | 0.79 | ALDH1A1 (0.66) | LMNAMAPTSIGMAR1HTR3EHTR3B | |
| SCHEMBL576454 | 0.79 | LMNA (0.67) | LMNACHRNA7MAPTSIGMAR1HTR3E | |
| SCHEMBL576814 | 0.79 | LMNA (0.67) | LMNACHRNA7MAPTSIGMAR1HTR3E | |
| SCHEMBL385012 | 0.79 | — | — | |
| SCHEMBL16924853 | 0.79 | LMNA (0.67) | LMNACHRNA7MAPTSIGMAR1HTR3E | |
| SCHEMBL164538 | 0.79 | LMNA (0.67) | LMNACHRNA7MAPTSIGMAR1HTR3E | |
| SCHEMBL8564919 | 0.77 | MAPT (0.61) | MAPTSIGMAR1HTR3EHTR3BADRB1 | |
| SCHEMBL19615056 | 0.74 | SMN1; SMN2 (0.53) | LMNAMAPTALDH1A1PKMHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1068200-B1 | 2,4,4-TRISUBSTITUTED-1,3-DIOXOLANE ANTIFUNGALS | JANSSEN PHARMACEUTICA NV (BE) | 2005-02-16 | — | — | EP | disclosed |
| US-6387906-B1 | DERMATOPHYTES | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-05-14 | — | — | US | disclosed |
| EP-1068200-A1 | 2,4,4-TRISUBSTITUTED-1,3-DIOXOLANE ANTIFUNGALS | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999002523-A1 | 2,4,4-TRISUBSTITUTED-1,3-DIOXOLANE ANTIFUNGALS | JANSSEN PHARMACEUTICA N.V. (BE) | 1999-01-21 | — | — | WO | disclosed |