Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 18/20 | 0.60 |
| ▸ | NOS3 | P29474 | 17/20 | 0.60 |
| ▸ | NOS2 | P35228 | 12/20 | 0.60 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6152955 | 0.89 | NOS3 (0.72) | NOS1NOS3NOS2 | |
| SCHEMBL6152196 | 0.88 | NOS3 (0.69) | NOS1NOS3NOS2 | |
| SCHEMBL6153424 | 0.86 | NOS1 (0.50) | NOS1NOS3NOS2CHRM2CHRM4 | |
| SCHEMBL6152435 | 0.85 | NOS3 (0.69) | NOS1NOS3NOS2 | |
| SCHEMBL5833437 | 0.85 | NOS1 (0.78) | NOS1NOS3NOS2CHRM2CHRM4 | |
| SCHEMBL5833985 | 0.84 | NOS3 (0.69) | NOS1NOS3NOS2 | |
| SCHEMBL6153425 | 0.83 | NOS3 (0.56) | NOS1NOS3NOS2DRD2HTR2A | |
| SCHEMBL5833190 | 0.82 | NOS1 (0.79) | NOS1NOS3NOS2CHRM2CHRM4 | |
| SCHEMBL255330 | 0.80 | NOS1 (0.57) | NOS1NOS3NOS2CHRM2CHRM4 | |
| SCHEMBL6153070 | 0.80 | NOS1 (0.75) | NOS1NOS3NOS2DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1084109-B1 | 2-AMINOPYRIDINES CONTAINING FUSED RING SUBSTITUENTS AS NITRIC OXIDE SYNTHASE INHIBITORS | PFIZER PROD INC (US) | 2005-01-26 | — | — | EP | disclosed |