Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 18/20 | 0.50 |
| ▸ | NOS3 | P29474 | 17/20 | 0.50 |
| ▸ | NOS2 | P35228 | 11/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6153422 | 0.86 | NOS1 (0.60) | NOS1NOS3NOS2CHRM2CHRM4 | |
| SCHEMBL6153197 | 0.86 | NOS1 (0.50) | NOS1NOS3NOS2 | |
| SCHEMBL5833188 | 0.83 | NOS1 (0.58) | NOS1NOS3NOS2CHRM2CHRM4 | |
| SCHEMBL6699624 | 0.76 | NOS1 (0.60) | NOS1NOS3NOS2CHRM2CHRM4 | |
| SCHEMBL6152955 | 0.75 | NOS3 (0.72) | NOS1NOS3NOS2 | |
| SCHEMBL6699620 | 0.75 | NOS1 (0.52) | NOS1NOS3NOS2CHRM2CHRM4 | |
| SCHEMBL6702757 | 0.75 | NOS1 (0.49) | NOS1NOS3NOS2CHRM2CHRM4 | |
| SCHEMBL6152196 | 0.74 | NOS3 (0.69) | NOS1NOS3NOS2 | |
| SCHEMBL7483824 | 0.74 | NOS1 (0.53) | NOS1NOS3NOS2CHRM2CHRM4 | |
| SCHEMBL6703557 | 0.73 | NOS1 (0.48) | NOS1NOS3NOS2CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1084109-B1 | 2-AMINOPYRIDINES CONTAINING FUSED RING SUBSTITUENTS AS NITRIC OXIDE SYNTHASE INHIBITORS | PFIZER PROD INC (US) | 2005-01-26 | — | — | EP | disclosed |