Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | FNTA | P49354 | 4/20 | 0.37 |
| ▸ | FNTB | P49356 | 4/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.37 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL822374 | 0.85 | — | — | |
| Lactic Acid SCHEMBL182252 | 0.77 | TP53 (0.50) | TP53ALDH1A1FNTAFNTBGRIK1 | |
| Benzoquinone SCHEMBL28329875 | 0.71 | MIF (0.39) | ALDH1A1FNTAFNTBGRIK1GRIK2 | |
| Lactic Acid SCHEMBL27710699 | 0.71 | TP53 (0.85) | TP53ALDH1A1 | |
| Lactic Acid SCHEMBL6264768 | 0.71 | TP53 (0.85) | TP53ALDH1A1 | |
| Lactic Acid SCHEMBL8948591 | 0.71 | TP53 (0.85) | TP53ALDH1A1 | |
| Lactic Acid SCHEMBL1018571 | 0.71 | TP53 (0.85) | TP53ALDH1A1 | |
| Lactic Acid SCHEMBL7778386 | 0.71 | TP53 (0.85) | TP53ALDH1A1 | |
| Lactic Acid SCHEMBL6943476 | 0.71 | TP53 (0.85) | TP53ALDH1A1 | |
| L-Lactic Acid SCHEMBL13165963 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050113579-A1 | Naphthalimide synthesis including amonafide synthesis and pharmaceutical preparations thereof | CHEMGENEX THERAPEUTICS, INC. | 2005-05-26 | — | — | US | claimed |
| EP-1499595-A1 | AMONAFIDE SALTS | Xanthus Life Sciences, Inc. (CA) | 2005-01-26 | — | — | EP | claimed |
| US-20040132763-A1 | Amonafide salts | XANTHUS LIFE SCIENCES, INC. | 2004-07-08 | — | — | US | claimed |
| US-20030203932-A1 | Amonafide salts | XANTHUS LIFE SCIENCES, INC. (CA) | 2003-10-30 | — | — | US | claimed |
| WO-2003089415-A1 | AMONAFIDE SALTS | XANTHUS LIFE SCIENCES, INC. (CA) | 2003-10-30 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040132763-A1 | Amonafide salts | OR10J3, NR4A1, OGFR | TP53 3222/4885ALDH1A1 1438/4885FNTA 3455/4885 |
| US-20050113579-A1 | Naphthalimide synthesis including amonafide synthesis and pharmaceutical preparations thereof | NME4, MFN2, NDUFAB1 | TP53 207/4885ALDH1A1 2221/4885FNTA 324/4885 |
| US-20030203932-A1 | Amonafide salts | OR10J3, NR4A1, OGFR | TP53 3222/4885ALDH1A1 1438/4885FNTA 3455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.