Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.66 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 4/20 | 0.45 |
| ▸ | FLT3 | P36888 | 4/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.42 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 3/20 | 0.39 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MELK | Q14680 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6153721 | 1.00 | ROCK2 (0.66) | ROCK2ROCK1KITFLT3PTGS1 | |
| SCHEMBL6153723 | 1.00 | ROCK2 (0.66) | ROCK2ROCK1KITFLT3PTGS1 | |
| SCHEMBL6154234 | 0.89 | ROCK2 (0.51) | ROCK2KITFLT3PTGS1PTGS2 | |
| SCHEMBL6154237 | 0.89 | ROCK2 (0.51) | ROCK2KITFLT3PTGS1PTGS2 | |
| SCHEMBL6156769 | 0.84 | ROCK2 (0.47) | ROCK2PTGS1PTGS2DGAT1PARP10 | |
| SCHEMBL6154351 | 0.84 | PTGS1 (0.52) | ROCK2ROCK1PTGS1PTGS2DGAT1 | |
| SCHEMBL6154356 | 0.84 | PTGS1 (0.52) | ROCK2ROCK1PTGS1PTGS2DGAT1 | |
| Cyanate SCHEMBL27865182 | 0.82 | PTGS1 (0.50) | ROCK2PTGS1PTGS2DGAT1PARP10 | |
| SCHEMBL6154534 | 0.82 | ACKR3 (0.48) | ROCK2FLT3PTGS1PTGS2JAK2 | |
| SCHEMBL25039539 | 0.81 | KDM1A (0.53) | ROCK2PTGS1PTGS2KCNQ3KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050182040-A1 | Benzamide derivatives | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2005-08-18 | — | — | US | disclosed |
| EP-1500643-A1 | BENZAMIDE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2005-01-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182040-A1 | Benzamide derivatives | ROCK1, ROCK2, NHERF1 | ROCK2 2/4885ROCK1 1/4885KIT 775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.