Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 4/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.41 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6153421 | 0.84 | AURKA (0.45) | AURKARPS6KB1SIRT2P2RX7HTR6 | |
| SCHEMBL6154234 | 0.84 | ROCK2 (0.51) | ROCK2PTGS1PTGS2DGAT1PARP10 | |
| SCHEMBL6153721 | 0.84 | ROCK2 (0.66) | ROCK2PTGS1PTGS2DGAT1PARP10 | |
| SCHEMBL6154056 | 0.84 | ROCK2 (0.66) | ROCK2PTGS1PTGS2DGAT1PARP10 | |
| SCHEMBL6153723 | 0.84 | ROCK2 (0.66) | ROCK2PTGS1PTGS2DGAT1PARP10 | |
| SCHEMBL6154237 | 0.84 | ROCK2 (0.51) | ROCK2PTGS1PTGS2DGAT1PARP10 | |
| SCHEMBL6153710 | 0.83 | RPS6KB1 (0.44) | AURKARPS6KB1SIRT2P2RX7HTR6 | |
| SCHEMBL6155049 | 0.83 | FLT3 (0.44) | AURKARPS6KB1SIRT2P2RX7HTR6 | |
| SCHEMBL6153331 | 0.81 | ROCK2 (0.40) | ROCK2AURKARPS6KB1PTGS1PTGS2 | |
| SCHEMBL6154534 | 0.81 | ACKR3 (0.48) | ROCK2RPS6KB1PTGS1PTGS2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050182040-A1 | Benzamide derivatives | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2005-08-18 | — | — | US | disclosed |
| EP-1500643-A1 | BENZAMIDE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2005-01-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182040-A1 | Benzamide derivatives | ROCK1, ROCK2, NHERF1 | ROCK2 2/4885AURKA 2136/4885RPS6KB1 1050/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.