Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MC4R | P32245 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6662252 | 0.90 | EPHX1 (0.35) | PNMTEPHX1HTR2AHTR2CHTR2B | |
| SCHEMBL6156534 | 0.81 | EPHX1 (0.41) | PNMTEPHX1ATMALDH1A1CHRM2 | |
| SCHEMBL6154240 | 0.74 | EPHX1 (0.40) | PNMTEPHX1HTR2CHTR2BSLC6A4 | |
| SCHEMBL6155403 | 0.71 | PNMT (0.50) | PNMTALDH1A1IDO1TDO2L3MBTL1 | |
| SCHEMBL6154126 | 0.70 | IDO1 (0.45) | PNMTHTR2AHTR2CHTR2BALDH1A1 | |
| SCHEMBL6154730 | 0.68 | CACNA2D1 (0.45) | PNMTEPHX1ALDH1A1SLC6A9 | |
| SCHEMBL28393834 | 0.65 | PNMT (0.51) | PNMTEPHX1HTR2AHTR2CHTR2B | |
| SCHEMBL22349750 | 0.65 | EPHX1 (0.49) | PNMTEPHX1HTR2AHTR2CHTR2B | |
| SCHEMBL28049523 | 0.65 | PNMT (0.45) | PNMTEPHX1HTR2AHTR2CHTR2B | |
| SCHEMBL255035 | 0.64 | PNMT (0.55) | PNMTHTR2AHTR2CHTR2BDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050065118-A1 | Organosulfur inhibitors of tyrosine phosphatases | METABASIS THERAPEUTICS, INC. | 2005-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065118-A1 | Organosulfur inhibitors of tyrosine phosphatases | PTPRS, PTPRJ, PTPRCAP | PNMT 330/4885EPHX1 1810/4885HTR2A 4126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.