Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.77 |
| ▸ | NPC1 | O15118 | 2/20 | 0.72 |
| ▸ | RAB9A | P51151 | 2/20 | 0.72 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.64 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.58 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | PPARG | P37231 | 2/20 | 0.53 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30810156 | 0.92 | DHODH (0.63) | DHODHNPC1RAB9APDCD1CD274 | |
| SCHEMBL5601228 | 0.91 | PKM (0.68) | DHODHNPC1RAB9AMEN1KMT2A | |
| SCHEMBL14075233 | 0.87 | DHODH (1.00) | DHODHNPC1RAB9APDCD1CD274 | |
| SCHEMBL505555 | 0.86 | NPC1 (0.61) | DHODHNPC1RAB9APDCD1CD274 | |
| SCHEMBL3711733 | 0.85 | DHODH (0.57) | DHODHNPC1RAB9AMEN1KMT2A | |
| SCHEMBL5117801 | 0.82 | POLB (0.57) | DHODHNPC1RAB9AMEN1KMT2A | |
| SCHEMBL14075242 | 0.82 | DHODH (0.88) | DHODHNPC1RAB9APDCD1CD274 | |
| SCHEMBL17769014 | 0.81 | F10 (0.66) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL7164649 | 0.81 | DHODH (0.64) | DHODHNPC1RAB9AMEN1KMT2A | |
| SCHEMBL2028671 | 0.80 | DHODH (0.86) | DHODHNPC1RAB9APDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603858-A2 | KCNQ CHANNEL MODULATING COMPOUNDS AND THEIR PHARMACEUTICAL USE | NeuroSearch A/S (DK) | 2005-12-14 | — | — | EP | disclosed |
| WO-2004080377-A2 | KCNQ CHANNEL MODULATING COMPOUNDS AND THEIR PHARMACEUTICAL USE | NEUROSEARCH A/S (DK) | 2004-09-23 | — | — | WO | disclosed |