Sugi Predict

Sugi Predict / Targets / FARSB

FARSB

Phenylalanine--tRNA ligase beta subunit · Q9NSD9 · FARSB on Sugi Atlas →

264 patent compounds predicted against FARSB, 215 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Tandutinib Tandutinib (SCHEMBL927974) 1.00 1/20
Pha-793887 Pha-793887 (SCHEMBL5110328) 1.00 1/20
Tandutinib Tandutinib (SCHEMBL29393910) 1.00 1/20
Tandutinib Tandutinib (SCHEMBL2478362) 0.98 1/20
SCHEMBL13330466 SCHEMBL13330466 0.98 1/20
Pha-793887 Pha-793887 (SCHEMBL31069494) 0.98 1/20
Tandutinib Tandutinib (SCHEMBL2496722) 0.93 1/20
SCHEMBL13330462 SCHEMBL13330462 0.93 1/20
SCHEMBL13524739 SCHEMBL13524739 0.89 1/20
SCHEMBL13529590 SCHEMBL13529590 0.88 1/20
SCHEMBL317630 SCHEMBL317630 0.86 1/20
SCHEMBL13330482 SCHEMBL13330482 0.86 1/20
SCHEMBL29460355 SCHEMBL29460355 0.86 1/20
SCHEMBL13330479 SCHEMBL13330479 0.85 1/20
SCHEMBL13330509 SCHEMBL13330509 0.85 1/20
SCHEMBL12694513 SCHEMBL12694513 0.83 1/20
SCHEMBL18159892 SCHEMBL18159892 0.82 1/20
SCHEMBL13168045 SCHEMBL13168045 0.82 1/20
SCHEMBL13355149 SCHEMBL13355149 0.82 1/20
SCHEMBL2472989 SCHEMBL2472989 0.81 1/20

Clinical trials — most relevant to FARSB by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Administration of Methionine in Patients With Pulmonary Alveolar Proteinosis by Mutation of the MARS Gene. PHASE1/PHASE2COMPLETED
Erythropoietic Protoporphyrias: Studies of the Natural History, Genotype-Phenotype Correlations, and Psychosocial Impact nanCOMPLETED
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others nanRECRUITING
Genetic Analysis of Hereditary Disorders of Hearing and Balance nanCOMPLETED
Protein Synthesis in the Brain of Patients With Fragile X Syndrome nanCOMPLETED
Impact of Mutations in Aminoacyl tRNA Synthetases on Protein Translation and Cellular Stress nanWITHDRAWN
Genetic Basis of Non Syndromic Congenital Diaphragmatic Hernia nanCOMPLETED
PREPL in Health and Disease nanACTIVE_NOT_RECRUITING
Molecular and Genetic Studies of Congenital Myopathies nanRECRUITING
Genetic Analysis of Inherited Urologic Malignant Disorders: Collection of Samples nanCOMPLETED
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN) nanRECRUITING
Phenotype/Genotype Correlations in Neuromuscular Disorders nanCOMPLETED
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
Role of Amino Acids and Genetic Disorder in Pathogenesis of Heart Failure nanUNKNOWN
Familial Partial Lipodystrophy Study nanCOMPLETED
Gene Analysis of Parkinson's Disease nanCOMPLETED
Phenotype/Genotype Correlations in Movement Disorders nanRECRUITING
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease nanUNKNOWN
Muscle Tissue Bank for Muscular Dystrophy nanCOMPLETED
Genes Associated With Development of Pulmonary Arterial Hypertension in Patients With Congenital Shunt Lesions nanRECRUITING
Mapping Novel Disease Genes for Dilated Cardiomyopathy nanCOMPLETED
New Strategies of Genetic Study of Patients With Oculocutaneous Albinism nanCOMPLETED
Registry and Natural History of Epilepsy-Dyskinesia Syndromes nanRECRUITING
Cerebellar Mutism Syndrome Study nanRECRUITING
Genetic Characterization of Parkinson's Disease nanCOMPLETED
Exome Evaluation in Patients Living With Diabetes Complicated by Charcot Neuroarthropathy. nanCOMPLETED
Genetic Investigations in Children With Developmental and Epileptic Encephalopathies in Ho Chi Minh City, Vietnam nanUNKNOWN
Exome Analysis in Hearing Impaired Patients nanUNKNOWN
Autosomal Dominant Retinitis Pigmentosa: Prevalence of Known Genes Identification of New Loci / Genes nanCOMPLETED
Genetic Analysis of Parkinson's Disease nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a FARSB binder may also engage these)

ProteinNameSimilarity
Q5R7F7 — 1.000 Q5R7F7 →
Q9WUA2 — 0.993 Q9WUA2 →
Q80Z29 — 0.948 Q80Z29 →
Q08DP0 — 0.948 Q08DP0 →
Q5R8T5 — 0.946 Q5R8T5 →
P36871 — 0.946 P36871 →
YARS1 Tyrosine--tRNA ligase, cytoplasmic 0.946 landscape →
P00949 — 0.946 P00949 →
Q8TCS8 — 0.945 Q8TCS8 →
Q4R5E4 — 0.944 Q4R5E4 →
Q8K1R3 — 0.944 Q8K1R3 →
Q5RDD3 — 0.944 Q5RDD3 →
P42932 — 0.944 P42932 →
Q5RCW2 — 0.943 Q5RCW2 →
Q9D0F9 — 0.943 Q9D0F9 →
Q5PQL4 — 0.943 Q5PQL4 →
O80526 — 0.942 O80526 →
Q2QZ86 — 0.942 Q2QZ86 →
NAMPT Nicotinamide phosphoribosyltransferase 0.942 landscape →
Q4KM49 — 0.942 Q4KM49 →
Q004B5 — 0.941 Q004B5 →
Q16134 — 0.941 Q16134 →
Q5ZMA6 — 0.941 Q5ZMA6 →
Q4R5J0 — 0.941 Q4R5J0 →
A0A0K9RL25 — 0.940 A0A0K9RL25 →
P38652 — 0.940 P38652 →
Q2QNG7 — 0.940 Q2QNG7 →
LARS1 Leucine--tRNA ligase, cytoplasmic 0.940 landscape →
Q91WQ3 — 0.940 Q91WQ3 →
Q6EE31 — 0.939 Q6EE31 →