Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.47 |
| ▸ | ATAD2 | Q6PL18 | 2/20 | 0.47 |
| ▸ | TOP2A | P11388 | 5/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6156066 | 0.84 | TOP2A (0.43) | BRD4ATAD2TOP2AHSP90AB1MAPK14 | |
| SCHEMBL6153952 | 0.84 | DDR1 (0.53) | TOP2AHSP90AB1ALOX15 | |
| SCHEMBL6155256 | 0.83 | TOP2A (0.42) | BRD4ATAD2TOP2AHSP90AB1MAPK14 | |
| SCHEMBL6154506 | 0.83 | ROCK2 (0.47) | BRD4ATAD2TOP2AHSP90AB1MAPK14 | |
| SCHEMBL6154711 | 0.83 | TOP2A (0.47) | BRD4ATAD2TOP2AHSP90AB1MAPK14 | |
| SCHEMBL19245321 | 0.82 | ALOX15 (0.60) | BRD4ATAD2MEN1KMT2AALDH1A1 | |
| SCHEMBL6153347 | 0.80 | PTK2 (0.41) | TOP2AHSP90AB1MAPK14IRAK4 | |
| SCHEMBL6154636 | 0.79 | TOP2A (0.46) | TOP2AHSP90AB1 | |
| SCHEMBL83376 | 0.77 | BRD4 (0.48) | BRD4ATAD2MEN1CYP2D6KMT2A | |
| SCHEMBL4144350 | 0.76 | IRAK4 (0.45) | BRD4ATAD2HDAC8KDM1AIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050182040-A1 | Benzamide derivatives | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2005-08-18 | — | — | US | disclosed |
| EP-1500643-A1 | BENZAMIDE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2005-01-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182040-A1 | Benzamide derivatives | ROCK1, ROCK2, NHERF1 | BRD4 865/4885ATAD2 2808/4885TOP2A 4307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.