Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.67 |
| ▸ | MGAM | O43451 | 1/20 | 0.67 |
| ▸ | SI | P14410 | 1/20 | 0.67 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.67 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.64 |
| ▸ | PHGDH | O43175 | 1/20 | 0.64 |
| ▸ | F2 | P00734 | 1/20 | 0.64 |
| ▸ | CA2 | P00918 | 1/20 | 0.64 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.64 |
| ▸ | ARG1 | P05089 | 1/20 | 0.64 |
| ▸ | LCK | P06239 | 1/20 | 0.64 |
| ▸ | HTR1A | P08908 | 1/20 | 0.64 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.64 |
| ▸ | ACE | P12821 | 1/20 | 0.64 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.64 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.64 |
| ▸ | IDO1 | P14902 | 1/20 | 0.64 |
| ▸ | MAOA | P21397 | 1/20 | 0.64 |
| ▸ | CNR1 | P21554 | 1/20 | 0.64 |
| ▸ | ACHE | P22303 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6155423 | 0.81 | CA2 (0.56) | GAAMGAMSIMGAM2PLA2G10 | |
| SCHEMBL3044656 | 0.81 | ALDH1A1 (0.70) | RAB9AALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL7104019 | 0.79 | HDAC3 (0.59) | GAAMGAMSIMGAM2PLA2G10 | |
| SCHEMBL7517330 | 0.79 | GUSB (0.53) | GAAMGAMSIMGAM2PLA2G10 | |
| SCHEMBL12767876 | 0.78 | ALDH1A1 (0.71) | RAB9AALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL12190100 | 0.76 | MEN1 (0.71) | RAB9AKMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL30369807 | 0.76 | NPC1 (1.00) | RAB9AKMT2AMEN1MAPTNPC1 | |
| SCHEMBL4254257 | 0.76 | NPC1 (1.00) | RAB9AKMT2AMEN1MAPTNPC1 | |
| SCHEMBL11921739 | 0.75 | RAB9A (0.74) | GAAMGAMSIMGAM2PLA2G10 | |
| SCHEMBL5450586 | 0.74 | ALDH1A1 (0.71) | GAAIDO1MAOARAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050065118-A1 | Organosulfur inhibitors of tyrosine phosphatases | METABASIS THERAPEUTICS, INC. | 2005-03-24 | — | — | US | disclosed |
| EP-1446110-A2 | ORGANOSULFUR INHIBITORS OF TYROSINE PHOSPHATASES | Structural Bioinformatics Inc. (US) | 2004-08-18 | — | — | EP | disclosed |
| WO-2003032916-A2 | ORGANOSULFUR INHIBITORS OF TYROSINE PHOSPHATASES | STRUCTURAL BIOINFORMATICS INC. (US) | 2003-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065118-A1 | Organosulfur inhibitors of tyrosine phosphatases | PTPRS, PTPRJ, PTPRCAP | GAA 2365/4885MGAM 3845/4885SI 4535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.