Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.56 |
| ▸ | KDR | P35968 | 4/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 5/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | PTGES | O14684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4077801 | 0.83 | ABL1 (0.64) | KMOKDRMAPK13MAPK12MAPK11 | |
| Bromide SCHEMBL4079422 | 0.82 | ABL1 (0.62) | KMOKDRMAPK13MAPK12MAPK11 | |
| SCHEMBL6153975 | 0.81 | ROCK2 (0.62) | EGFRCSNK2A1MEN1ALDH1A1MAPT | |
| SCHEMBL6155763 | 0.80 | EGFR (0.48) | EGFRCSNK2A1MEN1ALDH1A1MAPT | |
| SCHEMBL6154673 | 0.80 | EGFR (0.50) | KDRMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL20379651 | 0.77 | KDR (0.68) | KMOKDRCSNK2A1MEN1ALDH1A1 | |
| SCHEMBL3605321 | 0.73 | KDR (0.58) | KDRMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6286786 | 0.73 | BAZ1A (0.65) | KDRMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL20500567 | 0.72 | KMO (0.54) | KMOMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL6160095 | 0.72 | ROCK2 (0.69) | CSNK2A1MEN1ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050065118-A1 | Organosulfur inhibitors of tyrosine phosphatases | METABASIS THERAPEUTICS, INC. | 2005-03-24 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065118-A1 | Organosulfur inhibitors of tyrosine phosphatases | PTPRS, PTPRJ, PTPRCAP | KMO 2929/4885KDR 2876/4885MAPK13 2118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.