Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | RXRA | P19793 | 2/20 | 0.44 |
| ▸ | RXRB | P28702 | 2/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6154639 | 0.89 | CYSLTR2 (0.43) | MRGPRX4KMT2AFFAR1SMN1; SMN2ALOX5 | |
| SCHEMBL6886818 | 0.88 | NPC1 (0.48) | NPC1RAB9ARXRARXRBMRGPRX4 | |
| SCHEMBL6155468 | 0.81 | NPC1 (0.42) | NPC1RAB9ARXRARXRBALDH1A1 | |
| SCHEMBL6155463 | 0.81 | VDR (0.44) | NPC1RAB9ARXRARXRBMRGPRX4 | |
| SCHEMBL6886666 | 0.77 | CYSLTR2 (0.40) | NPC1RAB9AMRGPRX4HSP90AA1L3MBTL1 | |
| SCHEMBL2106608 | 0.76 | MRGPRX4 (0.42) | MRGPRX4FFAR1TP53PKMNFKB1 | |
| SCHEMBL6155474 | 0.76 | CYSLTR2 (0.45) | MRGPRX4KMT2AFFAR1SMN1; SMN2ALOX5 | |
| SCHEMBL15613832 | 0.72 | NPC1 (0.57) | NPC1RAB9ARXRARXRBMRGPRX4 | |
| SCHEMBL2785504 | 0.72 | CYSLTR2 (0.40) | ALDH1A1TSHRMEN1KMT2AFFAR1 | |
| SCHEMBL6155671 | 0.71 | NR4A2 (0.43) | MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1124779-B1 | VITAMIN D ANALOGUES | GALDERMA RES & DEV (FR) | 2005-02-02 | — | — | EP | disclosed |
| EP-1124779-A1 | VITAMIN D ANALOGUES | Galderma Research & Development, S.N.C. (FR) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000026167-A1 | VITAMIN D ANALOGUES | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2000-05-11 | — | — | WO | disclosed |