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SCHEMBL6155477

SCHEMBL6155477

CC(=CC=CC(=O)O)c1cccc(C#Cc2ccc(C(C)(C)O[SiH2]C(C)(C)C)c(C(C)(C)O[SiH2]C(C)(C)C)c2)c1

nearest known ligand 0.33

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ RARA P10276 2/20 0.33
▸ RARB P10826 2/20 0.33
▸ RARG P13631 2/20 0.33
▸ RXRA P19793 2/20 0.33
▸ RXRB P28702 1/20 0.33
▸ RXRG P48443 1/20 0.33
▸ FFAR1 O14842 1/20 0.30
▸ ACACB O00763 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6155431 0.83 ACACB (0.42) ACACB
SCHEMBL6155834 0.82 RARA (0.33) RARARARBRARGRXRARXRB
SCHEMBL6155650 0.79 MRGPRX4 (0.42) —
SCHEMBL6155470 0.71 BACE1 (0.35) RARARARBRARGRXRARXRB
SCHEMBL6881366 0.71 BACE1 (0.35) RARARARBRARGRXRARXRB
SCHEMBL6881362 0.71 BACE1 (0.35) RARARARBRARGRXRARXRB
SCHEMBL6881369 0.71 RARA (0.32) RARARARBRARGRXRARXRB
SCHEMBL6155584 0.67 VDR (0.36) —
SCHEMBL6156016 0.67 VDR (0.32) —
SCHEMBL6155760 0.65 VDR (0.42) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1124779-B1 VITAMIN D ANALOGUES GALDERMA RES & DEV (FR) 2005-02-02 — — EP disclosed
EP-1124779-A1 VITAMIN D ANALOGUES Galderma Research & Development, S.N.C. (FR) 2001-08-22 — — EP disclosed
WO-2000026167-A1 VITAMIN D ANALOGUES GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) 2000-05-11 — — WO disclosed