SCHEMBL6155759

SCHEMBL6155759

CC(CCCC(C)(C)O)c1cccc(COc2ccc(C(O[SiH](C)C)C(C)(C)C)c(C(O[SiH](C)C)C(C)(C)C)c2)c1

nearest known ligand 0.36

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYSLTR2 Q9NS75 1/20 0.36
CYSLTR1 Q9Y271 1/20 0.36
MAOB P27338 2/20 0.34
KDM4E B2RXH2 1/20 0.34
RAB9A P51151 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
PTGER3 P43115 1/20 0.33
GRM5 P41594 1/20 0.33
MRGPRX4 Q96LA9 1/20 0.33
FFAR1 O14842 2/20 0.33
CYP4F2 P78329 1/20 0.33
CYP4A11 Q02928 1/20 0.33
BCHE P06276 1/20 0.32
ADAMTS4 O75173 2/20 0.31
MMP13 P45452 2/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6154980 0.92 PTGER3 (0.33) CYSLTR2CYSLTR1MAOBSMN1; SMN2PTGER3
SCHEMBL6878848 0.87 CYSLTR2 (0.38) CYSLTR2CYSLTR1MAOBSMN1; SMN2PTGER3
SCHEMBL6155131 0.82 CYSLTR2 (0.36) CYSLTR2CYSLTR1KDM4ERAB9ASMN1; SMN2
SCHEMBL6158466 0.81 NOS1 (0.37) CYSLTR2CYSLTR1MAOBSMN1; SMN2FFAR1
SCHEMBL2107789 0.78 MRGPRX4 (0.44) CYSLTR2CYSLTR1GRM5MRGPRX4FFAR1
SCHEMBL2107787 0.77 VDR (0.40) CYSLTR2CYSLTR1MAOBPTGER3MRGPRX4
SCHEMBL6884382 0.76 MAOB (0.50) MAOBRAB9ASMN1; SMN2MRGPRX4
SCHEMBL6155762 0.72 CYSLTR2 (0.36) CYSLTR2CYSLTR1MAOBKDM4ERAB9A
SCHEMBL6155769 0.72 CYSLTR2 (0.35) CYSLTR2CYSLTR1MAOBKDM4ERAB9A
SCHEMBL6885668 0.72 MRGPRX4 (0.35) MAOBRAB9ASMN1; SMN2MRGPRX4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1124779-B1 VITAMIN D ANALOGUES GALDERMA RES & DEV (FR) 2005-02-02 EP disclosed
US-6689922-B1 BIAROMATIC COMPOUNDS WHICH ARE ANALOGUES OF VITAMIN D HAVE A MARKED ACTIVITY IN THE FIELDS OF CELL DIFFERENTIATION AND PROLIFERATION GALDERMA RESEARCH & DEVELOPMENT S.N.C. (FR) 2004-02-10 US disclosed
EP-1124779-A1 VITAMIN D ANALOGUES Galderma Research & Development, S.N.C. (FR) 2001-08-22 EP disclosed
WO-2000026167-A1 VITAMIN D ANALOGUES GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) 2000-05-11 WO disclosed