Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.72 |
| ▸ | GAA | P10253 | 9/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.72 |
| ▸ | MEN1 | O00255 | 8/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.72 |
| ▸ | HTT | P42858 | 3/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NPY1R | P25929 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6667399 | 0.78 | MAPT (0.61) | MAPTALDH1A1GAAKMT2AMEN1 | |
| SCHEMBL11921405 | 0.77 | RAB9A (0.68) | MAPTALDH1A1GAAKMT2AMEN1 | |
| SCHEMBL19472707 | 0.76 | POLB (0.61) | MAPTALDH1A1GAAKMT2AMEN1 | |
| SCHEMBL6155654 | 0.76 | MAPT (0.58) | MAPTALDH1A1GAAKMT2AMEN1 | |
| SCHEMBL6662554 | 0.75 | MAPT (0.55) | MAPTALDH1A1GAAKMT2AMEN1 | |
| SCHEMBL404368 | 0.74 | NPC1 (0.63) | MAPTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL403441 | 0.73 | NPC1 (0.63) | MAPTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL5450507 | 0.73 | ALDH1A1 (0.61) | MAPTALDH1A1GAAKMT2AMEN1 | |
| SCHEMBL6155423 | 0.70 | CA2 (0.56) | MAPTALDH1A1GAAKMT2AMEN1 | |
| SCHEMBL6810876 | 0.70 | MAPT (0.75) | MAPTALDH1A1GAAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050065118-A1 | Organosulfur inhibitors of tyrosine phosphatases | METABASIS THERAPEUTICS, INC. | 2005-03-24 | — | — | US | disclosed |
| EP-1446110-A2 | ORGANOSULFUR INHIBITORS OF TYROSINE PHOSPHATASES | Structural Bioinformatics Inc. (US) | 2004-08-18 | — | — | EP | disclosed |
| WO-2003032916-A2 | ORGANOSULFUR INHIBITORS OF TYROSINE PHOSPHATASES | STRUCTURAL BIOINFORMATICS INC. (US) | 2003-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065118-A1 | Organosulfur inhibitors of tyrosine phosphatases | PTPRS, PTPRJ, PTPRCAP | MAPT 3318/4885ALDH1A1 961/4885GAA 2365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.