Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 15/20 | 0.80 |
| ▸ | ZAP70 | P43403 | 4/20 | 0.80 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.80 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.79 |
| ▸ | BTK | Q06187 | 1/20 | 0.79 |
| ▸ | ITK | Q08881 | 1/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.61 |
| ▸ | CDK1 | P06493 | 2/20 | 0.58 |
| ▸ | PRKCA | P17252 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | STAT6 | P42226 | 1/20 | 0.57 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1222899 | 0.89 | SYK (1.00) | SYKZAP70CAMK1DPRKCEBTK | |
| SCHEMBL29794661 | 0.89 | SYK (1.00) | SYKZAP70CAMK1DPRKCEBTK | |
| SCHEMBL6157007 | 0.88 | SYK (0.79) | SYKZAP70CAMK1DPRKCEBTK | |
| SCHEMBL29794721 | 0.83 | SYK (1.00) | SYKZAP70CAMK1DPRKCEBTK | |
| SCHEMBL4714405 | 0.83 | SYK (1.00) | SYKZAP70CAMK1DPRKCEBTK | |
| SCHEMBL4710801 | 0.76 | SYK (0.76) | SYKZAP70CAMK1DPRKCEBTK | |
| SCHEMBL29794716 | 0.76 | SYK (1.00) | SYKZAP70CAMK1DPRKCEBTK | |
| SCHEMBL2383949 | 0.76 | SYK (1.00) | SYKZAP70CAMK1DPRKCEBTK | |
| SCHEMBL14923850 | 0.75 | SYK (0.71) | SYKZAP70CAMK1DPRKCEBTK | |
| SCHEMBL6156796 | 0.75 | SYK (0.71) | SYKZAP70CAMK1DPRKCEBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1184376-B1 | NOVEL HETEROCYCLIC CARBOXAMIDE DERIVATIVES | YAMANOUCHI PHARMA CO LTD (JP) | 2005-02-02 | — | — | EP | disclosed |
| US-6797706-B1 | Heterocyclecarboxamide derivative | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2004-09-28 | — | — | US | disclosed |
| EP-1184376-A1 | NOVEL HETEROCYCLIC CARBOXAMIDE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2002-03-06 | — | — | EP | disclosed |