Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 8/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.43 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.39 |
| ▸ | MAP1LC3A | Q9H492 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLQ | O75417 | 1/20 | 0.38 |
| ▸ | ALB | P02768 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6156465 | 1.00 | HSP90AB1 (0.43) | HSP90AB1HSP90AA1MAP1LC3BMAP1LC3AKDM4E | |
| SCHEMBL8444987 | 0.76 | HSP90AB1 (0.49) | HSP90AB1HSP90AA1MAP1LC3BMAP1LC3AKDM4E | |
| SCHEMBL6156108 | 0.76 | HSP90AB1 (0.49) | HSP90AB1HSP90AA1MAP1LC3BMAP1LC3AKDM4E | |
| SCHEMBL6157755 | 0.75 | HSP90AA1 (0.42) | HSP90AB1HSP90AA1MAP1LC3BMAP1LC3AKDM4E | |
| SCHEMBL6867189 | 0.74 | KDM4E (0.51) | HSP90AB1HSP90AA1MAP1LC3BMAP1LC3AKDM4E | |
| SCHEMBL6867185 | 0.74 | KDM4E (0.51) | HSP90AB1HSP90AA1MAP1LC3BMAP1LC3AKDM4E | |
| SCHEMBL6938077 | 0.74 | HSP90AB1 (0.46) | HSP90AB1HSP90AA1MAP1LC3BMAP1LC3AKDM4E | |
| SCHEMBL6938071 | 0.74 | HSP90AB1 (0.46) | HSP90AB1HSP90AA1MAP1LC3BMAP1LC3AKDM4E | |
| SCHEMBL6160624 | 0.73 | HSP90AB1 (0.47) | HSP90AB1HSP90AA1MAP1LC3BMAP1LC3AKDM4E | |
| SCHEMBL7743197 | 0.73 | HSP90AB1 (0.47) | HSP90AB1HSP90AA1MAP1LC3BMAP1LC3AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0894805-B1 | Ribose substituted aromatic derivatives, their preparation and use as medicaments | AVENTIS PHARMA SA (FR) | 2005-02-09 | — | — | EP | disclosed |
| EP-0894805-A1 | Ribose substituted aromatic derivatives, their preparation and use as medicaments | HOECHST MARION ROUSSEL (FR) | 1999-02-03 | — | — | EP | disclosed |