Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.66 |
| ▸ | P2RX1 | P51575 | 3/20 | 0.59 |
| ▸ | RHOC | P08134 | 3/20 | 0.57 |
| ▸ | RHOA | P61586 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.49 |
| ▸ | JUN | P05412 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17838656 | 0.87 | TRPV1 (0.71) | HDAC3HDAC6HDAC8P2RX1LMNA | |
| SCHEMBL27759009 | 0.86 | LMNA (0.76) | P2RX1RHOCRHOALMNATRPV1 | |
| SCHEMBL678064 | 0.81 | PTGS1 (0.77) | HDAC3HDAC6HDAC8P2RX1RHOC | |
| SCHEMBL2914683 | 0.79 | P2RX1 (0.74) | HDAC3HDAC6HDAC8P2RX1LMNA | |
| SCHEMBL12841602 | 0.78 | RHOC (0.78) | HDAC3HDAC6HDAC8P2RX1RHOC | |
| SCHEMBL5470561 | 0.77 | MEN1 (0.58) | RHOCRHOALMNA | |
| SCHEMBL28328407 | 0.77 | MLYCD (0.58) | P2RX1RHOCRHOALMNARAB9A | |
| SCHEMBL4188342 | 0.77 | NPC1 (0.52) | HDAC3HDAC6HDAC8LMNANPC1 | |
| SCHEMBL15603558 | 0.76 | P2RX1 (0.69) | HDAC3HDAC6HDAC8P2RX1RHOC | |
| SCHEMBL3246188 | 0.75 | P2RX1 (0.65) | HDAC3HDAC6HDAC8P2RX1RHOC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050065118-A1 | Organosulfur inhibitors of tyrosine phosphatases | METABASIS THERAPEUTICS, INC. | 2005-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065118-A1 | Organosulfur inhibitors of tyrosine phosphatases | PTPRS, PTPRJ, PTPRCAP | HDAC3 3036/4885HDAC6 483/4885HDAC8 1797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.