Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.32 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.31 |
| ▸ | USP8 | P40818 | 1/20 | 0.31 |
| ▸ | USP7 | Q93009 | 1/20 | 0.31 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15155502 | 0.82 | CYP11B1 (0.39) | CYP11B1CYP11B2USP8USP7 | |
| SCHEMBL8451921 | 0.76 | MAP4K4 (0.40) | GABRG2GABRB3GABRA5GABRA3CYP11B1 | |
| SCHEMBL2049864 | 0.76 | S1PR2 (0.37) | PTPN1POLB | |
| SCHEMBL2050214 | 0.76 | PTPN1 (0.34) | PTPN1LMNA | |
| SCHEMBL1206349 | 0.74 | ESR2 (0.44) | GABRG2GABRB3GABRA5GABRA3USP8 | |
| SCHEMBL2052765 | 0.73 | CHRM5 (0.35) | PTPN1CYP11B2AR | |
| SCHEMBL1804807 | 0.71 | AR (0.43) | AR | |
| SCHEMBL5517638 | 0.69 | ADORA1 (0.35) | TRPV4CYP11B1CYP11B2 | |
| SCHEMBL2224755 | 0.69 | AR (0.45) | POLBARLMNA | |
| SCHEMBL3288797 | 0.69 | GABRG2 (0.47) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370528-B1 | MCH ANTAGONISTS AND THEIR USE IN THE TREATMENT OF OBESITY | SCHERING CORP (US) | 2005-06-08 | — | — | EP | disclosed |