Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 15/20 | 0.43 |
| ▸ | PGR | P06401 | 5/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | MPL | P40238 | 2/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8809452 | 0.77 | CTSS (0.47) | ARCTSSCTSK | |
| SCHEMBL8451921 | 0.75 | MAP4K4 (0.40) | — | |
| SCHEMBL2431532 | 0.73 | KIF11 (0.38) | KIF11 | |
| SCHEMBL134889 | 0.71 | KDM5A (0.36) | ARPGRKIF11 | |
| SCHEMBL5517638 | 0.71 | ADORA1 (0.35) | — | |
| SCHEMBL6159211 | 0.71 | SCN9A (0.33) | AR | |
| SCHEMBL5325379 | 0.70 | TSHR (0.39) | — | |
| SCHEMBL15141384 | 0.69 | AR (0.53) | ARPGRRXRARXRBRXRG | |
| SCHEMBL22636009 | 0.69 | KIF11 (0.47) | ARPGRKIF11 | |
| SCHEMBL31030963 | 0.69 | MPL (0.55) | ARCTSSCTSKKIF11MPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4682207-B2 | — | — | 2011-05-11 | — | — | JP | claimed |
| EP-1797042-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-06-20 | — | — | EP | claimed |
| WO-2006034804-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-04-06 | — | — | WO | claimed |