⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL559604 | 0.67 | TP53 (0.38) | — | |
| SCHEMBL27910344 | 0.67 | TP53 (0.53) | — | |
| SCHEMBL28215974 | 0.64 | TP53 (0.36) | — | |
| SCHEMBL3145152 | 0.64 | ALDH1A1 (0.42) | — | |
| SCHEMBL537208 | 0.64 | TP53 (0.37) | — | |
| SCHEMBL1898955 | 0.61 | — | — | |
| SCHEMBL236564 | 0.61 | — | — | |
| SCHEMBL1680305 | 0.61 | — | — | |
| SCHEMBL1680345 | 0.61 | — | — | |
| SCHEMBL20465806 | 0.61 | TP53 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023077049-A1 | METHODS OF PREPARING 6-MEMBERED AZA-HETEROCYCLIC CONTAINING DELTA-OPIOID RECEPTOR MODULATING COMPOUNDS | TREVENA, INC. (US) | 2023-05-04 | — | — | WO | disclosed |
| CN-106220614-B | Pyridone/pyrazinones, preparation method and application method | 吉利德康涅狄格有限公司 | 2019-07-16 | — | — | CN | disclosed |
| CN-109651624-A | A kind of high tenacity is freeze proof/heat resistanceheat resistant/antibacterial plant polyphenol nano-cellulose conductive hydrogel preparation method | 福建农林大学 | 2019-04-19 | — | — | CN | disclosed |
| CN-104428299-B | 5- azaindazole compounds and its application method | 霍夫曼-拉罗奇有限公司 | 2018-05-11 | — | — | CN | disclosed |
| CN-107428708-A | Benzoxazine low temperature cure composition | 亨斯迈先进材料美国有限责任公司 | 2017-12-01 | — | — | CN | disclosed |
| CN-107253963-A | Pyridone and azepine pyridinone compounds and application method | 吉利德康涅狄格有限公司 | 2017-10-17 | — | — | CN | disclosed |
| CN-107011348-A | It is used as the heteroaryl pyridines ketone and azepine pyridinone compounds of the inhibitor of BTK activity | 霍夫曼-拉罗奇有限公司 | 2017-08-04 | — | — | CN | disclosed |
| CN-103038233-B | Pyridone and azapyridone compounds and methods of use | 吉利德康涅狄格有限公司 | 2017-06-20 | — | — | CN | disclosed |
| CN-104024233-B | Anticancer benzopyrazines through inhibition of FGFR kinase | 阿斯特克斯治疗有限公司 | 2017-05-24 | — | — | CN | disclosed |
| CN-104125959-B | Heteroaryl pyridone and aza-pyridone compounds as inhibitors of BTK activity | 霍夫曼-拉罗奇有限公司 | 2017-05-03 | — | — | CN | disclosed |
| EP-1341766-B1 | IMIDAZOLONE DERIVATIVES FOR THE TREATMENT OF VIRAL DISEASES | HOFFMANN LA ROCHE (CH) | 2005-10-26 | — | — | EP | disclosed |
| EP-1341766-A1 | IMIDAZOLONE DERIVATIVES FOR THE TREATMENT OF VIRAL DISEASES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-09-10 | — | — | EP | disclosed |
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6518293-B2 | Inhibitors of the human immunodeficiency virus reverse transcriptase enzyme which is involved in viral replication. | HOFFMANN-LA ROCHE INC. | 2003-02-11 | — | — | US | disclosed |
| US-20020107272-A1 | Anti-HIV imidazolone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-08 | — | — | US | disclosed |
| WO-2002042279-A1 | IMIDAZOLONE DERIVATIVES FOR THE TREATMENT OF VIRAL DISEASES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-30 | — | — | WO | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |