Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 6/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 2/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 4/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | KLK7 | P49862 | 1/20 | 0.31 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6158942 | 0.82 | CASP1 (0.54) | CASP1CA4MMP1MMP2CASP3 | |
| SCHEMBL6160566 | 0.82 | CASP1 (0.45) | CASP1CA12MMP9MMP1MMP2 | |
| SCHEMBL6159612 | 0.82 | CASP1 (0.58) | CASP1MMP9MMP1MMP2MMP8 | |
| SCHEMBL6158140 | 0.81 | CASP1 (0.51) | CASP1MMP9MMP1MMP2MMP8 | |
| SCHEMBL7415844 | 0.81 | CASP1 (0.48) | CASP1 | |
| SCHEMBL6159608 | 0.80 | CASP1 (0.43) | CASP1 | |
| SCHEMBL6159642 | 0.79 | CASP1 (0.49) | CASP1CASP3 | |
| SCHEMBL7420318 | 0.79 | CASP3 (0.45) | CASP1CASP3 | |
| SCHEMBL7425857 | 0.79 | CASP1 (0.41) | CASP1 | |
| SCHEMBL6159902 | 0.79 | CASP1 (0.43) | CASP1MMP9MMP1MMP2MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082127-B1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1BETA CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2005-06-22 | — | — | EP | disclosed |