Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 6/20 | 0.43 |
| ▸ | MMP2 | P08253 | 3/20 | 0.33 |
| ▸ | MMP1 | P03956 | 2/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 5/20 | 0.33 |
| ▸ | CASP8 | Q14790 | 3/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 2/20 | 0.31 |
| ▸ | REN | P00797 | 1/20 | 0.30 |
| ▸ | MMP3 | P08254 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6158942 | 0.88 | CASP1 (0.54) | CASP1MMP2MMP1CASP3CASP8 | |
| SCHEMBL6159573 | 0.88 | CASP1 (0.58) | CASP1 | |
| SCHEMBL6158140 | 0.87 | CASP1 (0.51) | CASP1MMP2MMP1MMP9MMP8 | |
| SCHEMBL7425857 | 0.84 | CASP1 (0.41) | CASP1 | |
| SCHEMBL6159608 | 0.83 | CASP1 (0.43) | CASP1 | |
| SCHEMBL6159512 | 0.82 | CASP1 (0.49) | CASP1MMP2MMP9MMP8CASP3 | |
| SCHEMBL6159906 | 0.82 | CASP1 (0.63) | CASP1MMP2MMP1MMP9MMP8 | |
| SCHEMBL6159714 | 0.82 | CASP1 (0.51) | CASP1MMP2MMP9MMP8CASP3 | |
| SCHEMBL6157498 | 0.82 | CASP1 (0.47) | CASP1MMP2MMP1MMP3 | |
| SCHEMBL6159126 | 0.81 | CASP1 (0.47) | CASP1CPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082127-B1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1BETA CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2005-06-22 | — | — | EP | claimed |
| EP-1082127-B1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1BETA CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2005-06-22 | — | — | EP | disclosed |