SCHEMBL6159936

SCHEMBL6159936

CC(=O)NCC1(c2ccccc2)CCN(C(=O)[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)CC1

nearest known ligand 0.59

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GHSR Q92847 13/20 0.59
TACR1 P25103 2/20 0.49
UGCG Q16739 2/20 0.43
CYP3A4 P08684 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27477229 1.00 GHSR (0.59) GHSRTACR1UGCGCYP3A4
SCHEMBL6162877 0.87 GHSR (0.46) GHSRTACR1UGCGCYP3A4
SCHEMBL6162851 0.86 GHSR (0.62) GHSRTACR1UGCGCYP3A4
SCHEMBL6162855 0.86 GHSR (0.62) GHSRTACR1UGCGCYP3A4
Hydrochloric Acid SCHEMBL6164166 0.85 GHSR (0.62) GHSRTACR1UGCGCYP3A4
Hydrochloric Acid SCHEMBL6163148 0.85 GHSR (0.62) GHSRTACR1UGCGCYP3A4
SCHEMBL27479333 0.85 GHSR (0.63) GHSRTACR1UGCGCYP3A4
SCHEMBL27479332 0.85 GHSR (0.63) GHSRTACR1UGCGCYP3A4
SCHEMBL6159933 0.84 GHSR (0.61) GHSRTACR1UGCGCYP3A4
SCHEMBL6165535 0.81 GHSR (0.59) GHSRUGCGCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0828754-B1 DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE PFIZER (US) 2005-02-02 EP claimed
EP-0828754-B1 DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE PFIZER (US) 2005-02-02 EP disclosed
CN-1143647-A Dipeptides which promote release of growth hormone PFIZER (US) 1997-02-26 CN disclosed