SCHEMBL6160131

SCHEMBL6160131

Cc1nc(Cl)c(Cl)n1CCCCN1CC=C(c2ccc(Cl)cc2)CC1

nearest known ligand 0.57

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 12/20 0.57
PARP1 P09874 2/20 0.48
DRD2 P14416 1/20 0.47
HTR1A P08908 1/20 0.46
HTR7 P34969 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5846884 0.94 SIGMAR1 (0.56) SIGMAR1PARP1DRD2HTR1AHTR7
SCHEMBL5847846 0.91 SIGMAR1 (0.55) SIGMAR1PARP1DRD2HTR7
SCHEMBL6160767 0.91 SIGMAR1 (0.53) SIGMAR1PARP1
Hydrochloric Acid SCHEMBL7059241 0.90 SIGMAR1 (0.47) SIGMAR1PARP1DRD2HTR1A
Hydrochloric Acid SCHEMBL6164686 0.90 SIGMAR1 (0.54) SIGMAR1PARP1DRD2HTR7
Hydrochloric Acid SCHEMBL6161849 0.90 SIGMAR1 (0.52) SIGMAR1PARP1
Hydrochloric Acid SCHEMBL6162378 0.90 SIGMAR1 (0.52) SIGMAR1PARP1
SCHEMBL5848354 0.88 SIGMAR1 (0.50) SIGMAR1PARP1DRD2
SCHEMBL5846215 0.83 SIGMAR1 (0.63) SIGMAR1PARP1DRD2HTR1AHTR7
SCHEMBL5847783 0.82 HTR7 (0.51) SIGMAR1PARP1HTR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0721455-B9 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS ESTEVE LABOR DR (ES) 2005-04-20 EP claimed
EP-1097698-B1 UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN ESTEVE LABOR DR (ES) 2003-05-07 EP claimed
EP-0721455-B1 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS ESTEVE LABOR DR (ES) 2002-12-11 EP claimed
US-6232329-B1 POSSESSING THERAPEUTIC ACTIVITY FOR THE TREATMENT OF ANXIETY, PSYCHOSIS, EPILEPSY, CONVULSION, MOTORICITY PROBLEMS, AMNESIA, CEREBROVASCULAR DISEASES OR SENILE DEMENTIA LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2001-05-15 US claimed
EP-1097698-A2 UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2001-05-09 EP claimed