Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.53 |
| ▸ | PARP1 | P09874 | 9/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6161849 | 0.99 | SIGMAR1 (0.52) | SIGMAR1PARP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6162378 | 0.99 | SIGMAR1 (0.52) | SIGMAR1PARP1ALDH1A1 | |
| SCHEMBL5848354 | 0.98 | SIGMAR1 (0.50) | SIGMAR1PARP1ALDH1A1 | |
| SCHEMBL5846884 | 0.92 | SIGMAR1 (0.56) | SIGMAR1PARP1 | |
| SCHEMBL6160131 | 0.91 | SIGMAR1 (0.57) | SIGMAR1PARP1 | |
| SCHEMBL5847846 | 0.89 | SIGMAR1 (0.55) | SIGMAR1PARP1 | |
| Hydrochloric Acid SCHEMBL6164686 | 0.88 | SIGMAR1 (0.54) | SIGMAR1PARP1 | |
| Hydrochloric Acid SCHEMBL7059241 | 0.88 | SIGMAR1 (0.47) | SIGMAR1PARP1 | |
| SCHEMBL5847783 | 0.86 | HTR7 (0.51) | SIGMAR1PARP1 | |
| Hydrochloric Acid SCHEMBL7058619 | 0.85 | HTR7 (0.50) | SIGMAR1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0721455-B9 | TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS | ESTEVE LABOR DR (ES) | 2005-04-20 | — | — | EP | claimed |
| EP-1097698-B1 | UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN | ESTEVE LABOR DR (ES) | 2003-05-07 | — | — | EP | claimed |
| EP-0721455-B1 | TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS | ESTEVE LABOR DR (ES) | 2002-12-11 | — | — | EP | claimed |
| US-6232329-B1 | POSSESSING THERAPEUTIC ACTIVITY FOR THE TREATMENT OF ANXIETY, PSYCHOSIS, EPILEPSY, CONVULSION, MOTORICITY PROBLEMS, AMNESIA, CEREBROVASCULAR DISEASES OR SENILE DEMENTIA | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2001-05-15 | — | — | US | claimed |
| EP-1097698-A2 | UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2001-05-09 | — | — | EP | claimed |
| US-5731331-A | Tetrahydropyridine-(or 4-hydroxypiperidine) alkylazoles | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1998-03-24 | — | — | US | claimed |
| WO-1996004287-A1 | TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1996-02-15 | — | — | WO | claimed |
| EP-0721455-B9 | TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS | ESTEVE LABOR DR (ES) | 2005-04-20 | — | — | EP | disclosed |
| EP-0721455-B1 | TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS | ESTEVE LABOR DR (ES) | 2002-12-11 | — | — | EP | disclosed |
| US-6232329-B1 | POSSESSING THERAPEUTIC ACTIVITY FOR THE TREATMENT OF ANXIETY, PSYCHOSIS, EPILEPSY, CONVULSION, MOTORICITY PROBLEMS, AMNESIA, CEREBROVASCULAR DISEASES OR SENILE DEMENTIA | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2001-05-15 | — | — | US | disclosed |
| US-5731331-A | Tetrahydropyridine-(or 4-hydroxypiperidine) alkylazoles | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1998-03-24 | — | — | US | disclosed |
| WO-1996004287-A1 | TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1996-02-15 | — | — | WO | disclosed |