Sugi Predict

Sugi Predict / Compounds / SCHEMBL616033

SCHEMBL616033

SCHEMBL616033

CC(=O)OC1=CCCCCC1=O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GSTP1 P09211 2/20 0.42
▸ PGR P06401 3/20 0.37
▸ ESR1 P03372 1/20 0.37
▸ CHRM2 P08172 1/20 0.37
▸ ADORA3 P0DMS8 1/20 0.37
▸ AR P10275 1/20 0.37
▸ CHRM1 P11229 1/20 0.37
▸ SLC6A2 P23975 1/20 0.37
▸ SLC6A3 Q01959 1/20 0.37
▸ HDAC4 P56524 1/20 0.35
▸ HDAC2 Q92769 1/20 0.35
▸ HDAC8 Q9BY41 1/20 0.35
▸ HDAC6 Q9UBN7 1/20 0.35
▸ GLA P06280 1/20 0.34
▸ GBA1 P04062 1/20 0.33
▸ CTSK P43235 1/20 0.33
▸ ALDH1A1 P00352 2/20 0.32
▸ TSHR P16473 1/20 0.32
▸ SMN1; SMN2 Q16637 1/20 0.32
▸ MAPT P10636 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16714050 0.94 GSTP1 (0.41) GSTP1PGRESR1CHRM2ADORA3
SCHEMBL4006610 0.86 GLA (0.37) PGRESR1CHRM2ADORA3AR
SCHEMBL7179832 0.75 GLA (0.30) GLA
SCHEMBL561717 0.75 PGR (0.40) GSTP1PGRESR1CHRM2ADORA3
SCHEMBL1695488 0.73 PGR (0.42) GSTP1PGRESR1CHRM2ADORA3
SCHEMBL11120187 0.73 PGR (0.39) GSTP1PGRESR1CHRM2ADORA3
SCHEMBL9816253 0.73 PGR (0.42) GSTP1PGRESR1CHRM2ADORA3
SCHEMBL1695480 0.73 PGR (0.42) GSTP1PGRESR1CHRM2ADORA3
SCHEMBL9333724 0.73 PGR (0.42) GSTP1PGRESR1CHRM2ADORA3
SCHEMBL9333728 0.73 PGR (0.42) GSTP1PGRESR1CHRM2ADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9907762-B2 Stabilized mutant opsin proteins UNIVERSITY OF WASHINGTON (US) 2018-03-06 — — US disclosed
US-20160045453-A1 STABILIZED MUTANT OPSIN PROTEINS UNIV WASHINGTON (US) 2016-02-18 — — US disclosed
US-9149446-B2 Stabilized mutant opsin proteins UNIVERSITY OF WASHINGTON (US) 2015-10-06 — — US disclosed
US-20130072443-A1 STABILIZED MUTANT OPSIN PROTEINS REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 2013-03-21 — — US disclosed
US-20120041073-A1 STABILIZED MUTANT OPSIN PROTEINS REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 2012-02-16 — — US disclosed
US-20040242704-A1 Stabilized mutant opsin proteins UNIVERSITY OF WASHINGTON, TECHTRANSFER - INVENTION LICENSING 2004-12-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040242704-A1 Stabilized mutant opsin proteins NR2E3, CRYZ, RBP1 GSTP1 2113/4885PGR 3957/4885ESR1 3402/4885
US-20160045453-A1 STABILIZED MUTANT OPSIN PROTEINS NR2E3, RBP1, CRYZ GSTP1 2740/4885PGR 3510/4885ESR1 3356/4885
US-20120041073-A1 STABILIZED MUTANT OPSIN PROTEINS NR2E3, CRYZ, RBP1 GSTP1 2113/4885PGR 3957/4885ESR1 3402/4885
US-20130072443-A1 STABILIZED MUTANT OPSIN PROTEINS NR2E3, CRYZ, RBP1 GSTP1 2113/4885PGR 3957/4885ESR1 3402/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.